Reuveny Ronen, DiMenna Fred J, Gunaratnam Cedric, Arad Avigdor D, McElvaney Gerry N, Susta Davide, Peled Michael, Moyna Niall M
1Centre for Preventive Medicine, School of Health and Human Performance, Dublin City University, Dublin, Ireland.
2Pulmonary Institute, Sheba Medical Center, Tel-HaShomer, Ramat Gan, affiliated with Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.
BMC Sports Sci Med Rehabil. 2020 Apr 13;12:9. doi: 10.1186/s13102-020-0159-z. eCollection 2020.
Exercise training provides benefits for individuals with cystic fibrosis; however, the optimal program is unclear. High-intensity interval training is safe and effective for improving 'functional capacity' in these individuals with peak rate of O uptake typically referenced. The ability to adjust submaximal rate of oxygen uptake (V̇O kinetics) might be more important for everyday function because maximal efforts are usually not undertaken. Moreover, the ability of high-intensity training to accelerate V̇O kinetics for individuals with cystic fibrosis could be enhanced with O supplementation during training.
Nine individuals with cystic fibrosis completed incremental cycling to limit of tolerance followed by 8 weeks of high-intensity interval cycling (2 sessions per week x ~ 45 min per session) either with ( = 5; O2+) or without (AMB) oxygen supplementation (100%). Each session involved work intervals at 70% of peak work rate followed by 60 s of recovery at 35%. For progression, duration of work intervals was increased according to participant tolerance.
Both groups experienced a significant increase in work-interval duration over the course of the intervention (O2+, 1736 ± 141 . 700 ± 154 s; AMB, 1463 ± 598 . 953 ± 253 s; = 0.000); however, the increase experienced by O2+ was greater ( = 0.027). During low-intensity constant-work-rate cycling, the V̇O mean response time was shortened post compared to pre training (O2+, 34 ± 11 . 44 ± 9 s; AMB, 39 ± 14 . 45 ± 17 s; = 0.000) while during high-intensity constant-work-rate cycling, time to exhaustion was increased (O2+, 1628 ± 163 . 705 ± 133 s; AMB, 1073 ± 633 . 690 ± 348 s; = 0.002) and blood [lactate] response was decreased (O2+, 4.5 ± 0.9 . 6.3 ± 1.4 mmol L; AMB, 4.5 ± 0.6 . 5.2 ± 1.4 mmol L; = 0.003). These positive adaptations were similar regardless of gas inspiration during training.
Eight weeks of high-intensity interval training for patients with cystic fibrosis accelerated V̇O kinetics and increased time to exhaustion. This provides some evidence that these patients may benefit from this type of exercise.
This study was retrospectively registered in the ISRTCN registry on 22/06/2019 (#ISRCTN13864650).
运动训练对囊性纤维化患者有益；然而，最佳方案尚不清楚。高强度间歇训练对于提高这些个体的“功能能力”是安全有效的，通常以峰值摄氧量作为参考。对于日常功能而言，调整次最大摄氧率（V̇O动力学）的能力可能更为重要，因为通常不会进行最大努力运动。此外，在训练期间补充氧气可能会增强高强度训练对囊性纤维化患者V̇O动力学的加速作用。
9名囊性纤维化患者完成递增式骑行至耐受极限，随后进行8周的高强度间歇骑行训练（每周2次，每次约45分钟），其中5名患者在训练中补充氧气（O2+组），另外4名患者不补充氧气（AMB组）。每次训练包括以峰值工作率的70%进行工作间歇，随后以35%的强度进行60秒的恢复。随着训练进程，根据参与者的耐受情况增加工作间歇的持续时间。
在干预过程中，两组的工作间歇持续时间均显著增加（O2+组，从1736±141秒增加到700±154秒；AMB组，从1463±598秒增加到953±253秒；P = 0.000）；然而，O2+组的增加幅度更大（P = 0.027）。在低强度恒定工作率骑行期间，与训练前相比训练后V̇O平均反应时间缩短（O2+组，从34±11秒缩短到44±9秒；AMB组，从39±14秒缩短到45±17秒；P = 0.000），而在高强度恒定工作率骑行期间，疲劳时间增加（O2+组，从1628±163秒增加到705±133秒；AMB组，从1073±633秒增加到690±348秒；P = 0.002），并且血乳酸反应降低（O2+组，从4.5±0.9毫摩尔/升降低到6.3±1.4毫摩尔/升；AMB组，从4.5±0.6毫摩尔/升降低到5.2±1.4毫摩尔/升；P = 0.003）。无论训练期间吸入何种气体，这些积极的适应性变化都是相似的。
对囊性纤维化患者进行8周的高强度间歇训练可加速V̇O动力学并增加疲劳时间。这提供了一些证据表明这些患者可能从这种类型的运动中获益。
本研究于2019年6月22日在ISRTCN注册中心进行回顾性注册（#ISRCTN13864650）。
