Wang Hao, Fu Hongxun, Fu Yefan, Jiang Lin, Wang Liye, Tong Haibin, Xie Zuoxu, Huang Peng, Sun Meiyan
College of Laboratory Medicine, Jilin Medical University, Jilin, China.
Key Laboratory of Micro/Nano and Ultra-precision Manufacturing, School of Mechatronic Engineering, Changchun University of Technology, Changchun, China.
Front Bioeng Biotechnol. 2023 Jan 6;10:1099616. doi: 10.3389/fbioe.2022.1099616. eCollection 2022.
Nanocomposite Hydrogels (NHs) are 3D molecular networks formed by physically or covalently crosslinking polymer with nanoparticles or nanostructures, which are particularly suitable for serving as carriers for drug delivery systems. Many articles pertaining to the applications of Nanocomposite Hydrogels for drug delivery have been published, however, the use of bibliometric and visualized analysis in this area remains unstudied. The purpose of this bibliometric study intended to comprehensively analyze the knowledge domain, research hotspots and frontiers associated with the applications of Nanocomposite Hydrogels for drug delivery. We identified and retrieved the publications concerning the applications of NHs for drug delivery between 2003 and 2022 from Web of Science Core Collection Bibliometric and visualized analysis was utilized in this investigative study. 631 articles meeting the inclusion criteria were identified and retrieved from WoSCC. Among those, 2,233 authors worldwide contributed in the studies, accompanied by an average annual article increase of 24.67%. The articles were co-authored by 764 institutions from 52 countries/regions, and China published the most, followed by Iran and the United States. Five institutions published more than 40 papers, namely Univ Tabriz ( = 79), Tabriz Univ Med Sci ( = 70), Islamic Azad Univ ( = 49), Payame Noor Univ ( = 42) and Texas A&M Univ ( = 41). The articles were published in 198 journals, among which the International Journal of Biological Macromolecules ( = 53) published the most articles, followed by Carbohydrate Polymers ( = 24) and ACS Applied Materials and Interfaces ( = 22). The top three journals most locally cited were Carbohydrate Polymers, Biomaterials and Advanced materials. The most productive author was Namazi H (29 articles), followed by Bardajee G (15 articles) and Zhang J (11 articles) and the researchers who worked closely with other ones usually published more papers. "Doxorubicin," "antibacterial" and "responsive hydrogels" represent the current research hotspots in this field and "cancer therapy" was a rising research topic in recent years. "(cancer) therapeutics" and "bioadhesive" represent the current research frontiers. This bibliometric and visualized analysis offered an investigative study and comprehensive understanding of publications regarding the applications of Nanocomposite Hydrogels for drug delivery from 2003 to 2022. The outcome of this study would provide insights for researchers in the field of Nanocomposite Hydrogels applications for drug delivery.
纳米复合水凝胶（NHs）是通过聚合物与纳米颗粒或纳米结构进行物理或共价交联形成的三维分子网络，特别适合用作药物递送系统的载体。许多关于纳米复合水凝胶在药物递送中应用的文章已经发表，然而，该领域的文献计量学和可视化分析仍未得到研究。本文献计量学研究旨在全面分析与纳米复合水凝胶在药物递送中应用相关的知识领域、研究热点和前沿。我们从科学网核心合集（Web of Science Core Collection）中识别并检索了2003年至2022年期间关于纳米复合水凝胶在药物递送中应用的出版物，并在本调查研究中采用了文献计量学和可视化分析。从科学网核心合集中识别并检索到631篇符合纳入标准的文章。其中，全球2233位作者参与了这些研究，文章年均增长24.67%。这些文章由来自52个国家/地区的764个机构共同撰写，中国发表的文章最多，其次是伊朗和美国。有5个机构发表了40多篇论文，分别是大不里士大学（Univ Tabriz，79篇）、大不里士医科大学（Tabriz Univ Med Sci，70篇）、伊斯兰阿扎德大学（Islamic Azad Univ，49篇）、帕亚梅农努尔大学（Payame Noor Univ，42篇）和德克萨斯A&M大学（Texas A&M Univ，41篇）。这些文章发表在198种期刊上，其中《国际生物大分子杂志》（International Journal of Biological Macromolecules，53篇）发表的文章最多，其次是《碳水化合物聚合物》（Carbohydrate Polymers，24篇）和《美国化学会应用材料与界面》（ACS Applied Materials and Interfaces，22篇）。本地被引次数最多的前三种期刊是《碳水化合物聚合物》《生物材料》和《先进材料》。发文量最多的作者是纳马齐·H（Namazi H，29篇），其次是巴尔达吉·G（Bardajee G，15篇）和张J（Zhang J，11篇），与其他作者密切合作的研究人员通常发表的论文更多。“阿霉素”“抗菌”和“响应性水凝胶”代表了该领域当前的研究热点，“癌症治疗”是近年来新兴的研究主题。“（癌症）治疗学”和“生物黏附”代表了当前的研究前沿。本文献计量学和可视化分析为2003年至2022年期间纳米复合水凝胶在药物递送中应用的出版物提供了一项调查研究和全面理解。本研究结果将为纳米复合水凝胶在药物递送应用领域的研究人员提供见解。
