Shuoxin Yin, Shuping Wang, Xinyue Zhang, Tao Zhang, Yuanneng Chen
Graduate School of Guangxi University of Chinese Medicine, Nanning, Guangxi, China.
Department of Gastroenterology, Ruikang Hospital Affiliated to Guangxi University of Chinese Medicine, Nanning, Guangxi, China.
Front Oncol. 2023 Jan 26;13:1092870. doi: 10.3389/fonc.2023.1092870. eCollection 2023.
Research on tumor organoids has developed rapidly over the past 20 years, but a systematic analysis of current research trends is lacking. Researchers in the field need relevant references and knowledge of current research hot spots. Bibliometric analysis and visualization is a systematic method of acquiring an in-depth understanding of the status of research on tumor organoids.
CiteSpace, VOSviewer and the Bibliometric Online Analysis Platform from the Web of Science Core Collection were used to analyze and predict publishing trends and research hot spots worldwide in the field of tumor organoids.
A total of 3,666 publications on tumor organoids were retrieved, and 2,939 eligible articles were included in the final analysis. The number of publications has grown significantly, with the United States of America as the leading country for research on tumor organoids. Among journals, published the largest number of articles. Harvard Medical School published the highest number of articles among all institutions. The Chinese Academy of Sciences was ranked highest among all contributing institutions on the importance of their publications. A trend in multi-disciplinary collaboration was observed in studies on tumor organoids. Keywords indicated that the current research largely concentrated on optimizing the construction of organoid models to use for medication development and screening in the clinical setting, and to provide patients with individualized treatment for gastric cancer and colorectal cancer, which are newly emerging research hotspots. Gastric and colorectal cancers were the top two tumors that have received increasing attention and have become the focal points of recent studies.
This study analyzed 2,939 publications covering the topic of tumor organoids. Although optimizing the construction of organoid models has always been a hot topic in this field, the application of tumor organoids to the development of medications and screenings will foster individualized treatment for patients, which is another emerging hot spot in this field of research.
在过去20年中，肿瘤类器官的研究发展迅速，但目前缺乏对研究趋势的系统分析。该领域的研究人员需要有关当前研究热点的相关参考文献和知识。文献计量分析和可视化是深入了解肿瘤类器官研究现状的系统方法。
使用CiteSpace、VOSviewer和来自科学网核心合集的文献计量在线分析平台，分析和预测全球肿瘤类器官领域的出版趋势和研究热点。
共检索到3666篇关于肿瘤类器官的出版物，最终分析纳入2939篇符合条件的文章。出版物数量显著增长，美国是肿瘤类器官研究的主要国家。在期刊方面，发表的文章数量最多。哈佛医学院在所有机构中发表的文章数量最多。中国科学院在所有贡献机构中，其出版物的重要性排名最高。在肿瘤类器官研究中观察到多学科合作的趋势。关键词表明，当前的研究主要集中在优化类器官模型的构建，以用于临床环境中的药物开发和筛选，并为胃癌和结直肠癌患者提供个性化治疗，这是新出现的研究热点。胃癌和结直肠癌是受到越来越多关注并已成为近期研究重点的前两种肿瘤。
本研究分析了2939篇涵盖肿瘤类器官主题的出版物。虽然优化类器官模型的构建一直是该领域的热门话题，但肿瘤类器官在药物开发和筛选中的应用将促进对患者的个性化治疗，这是该研究领域的另一个新出现的热点。
