Gupta S, Imam A
Am J Med. 1987 May;82(5):1027-30. doi: 10.1016/0002-9343(87)90169-0.
An HTLV-III/LAV antibody-positive homosexual man in whom disseminated malignant melanoma developed is described. Immunologic analysis revealed an increase in suppressor/cytotoxic phenotype (Leu-2-positive) T cells, depressed proliferative response to mitogens, decreased proportions of T cells with interleukin-2 receptors but normal production of both interleukin-2 and interleukin-1, cutaneous anergy, elevated levels of serum IgG and IgA, and presence of autoantibodies against smooth muscle and parietal cells of the stomach. This case stresses the need for reporting all types of neoplasms associated with exposure to HTLV-III/LAV so that their true incidence in the population "at risk" for the acquired immune deficiency syndrome can be determined.
本文描述了一名HTLV-III/LAV抗体呈阳性的同性恋男子，该男子发生了播散性恶性黑色素瘤。免疫分析显示，抑制/细胞毒性表型（Leu-2阳性）T细胞增加，对有丝分裂原的增殖反应降低，白细胞介素-2受体阳性的T细胞比例下降，但白细胞介素-2和白细胞介素-1的产生正常，皮肤无反应性，血清IgG和IgA水平升高，以及存在针对胃平滑肌和壁细胞的自身抗体。该病例强调了报告与接触HTLV-III/LAV相关的所有类型肿瘤的必要性，以便能够确定在获得性免疫缺陷综合征“高危”人群中的真实发病率。
