Nicholson J K, Echenberg D F, Jones B M, Jaffe H W, Feorino P M, McDougal J S
Clin Immunol Immunopathol. 1986 Sep;40(3):505-14. doi: 10.1016/0090-1229(86)90195-9.
The number of lymphocytes bearing the Leu 2+ or T8+ (suppressor/cytotoxic) phenotype is elevated in asymptomatic homosexual men. By two-color immunofluorescence using paired monoclonal antibodies (alpha-Leu 2 and alpha-Leu 15, alpha-Leu 2 and alpha-Leu 7, alpha-Leu 7 and alpha-Leu 11), we enumerated phenotypic subpopulations that are associated with cytotoxic, suppressor, or natural killer function. Both cytotoxic (Leu 2+15-) and suppressor (bright Leu 2+15+) cell populations are elevated in homosexual men. Homosexual men who have been exposed to human T-lymphotropic virus type III/lymphadenopathy-associated virus (HTLV-III/LAV) have higher numbers of Leu 2+15- and Leu 2+7- cells than homosexual men who have not been exposed. Phenotypic subpopulations (dim Leu 2+ Leu 15+ and Leu 7-11+) that are associated with the most potent natural killer activity (against K562 target cells) were not found to be elevated in homosexual men.
无症状同性恋男性中携带Leu 2+或T8+（抑制/细胞毒性）表型的淋巴细胞数量增加。通过使用配对单克隆抗体（α-Leu 2和α-Leu 15、α-Leu 2和α-Leu 7、α-Leu 7和α-Leu 11）的双色免疫荧光法，我们对与细胞毒性、抑制或自然杀伤功能相关的表型亚群进行了计数。同性恋男性中的细胞毒性（Leu 2+15-）和抑制（亮Leu 2+15+）细胞群体均增加。接触过人类嗜T淋巴细胞病毒III型/淋巴结病相关病毒（HTLV-III/LAV）的同性恋男性比未接触过的同性恋男性有更多的Leu 2+15-和Leu 2+7-细胞。未发现与最有效的自然杀伤活性（针对K562靶细胞）相关的表型亚群（暗Leu 2+ Leu 15+和Leu 7-11+）在同性恋男性中增加。
