Lu Weizhuo, Wen Jiyue
Medical Branch, Hefei Technology College, Hefei, China.
Department of Pharmacology, School of Basic Medical Sciences, Anhui Medical University, Hefei, China.
Metab Brain Dis. 2023 Jan;38(1):163-176. doi: 10.1007/s11011-022-01130-1. Epub 2022 Dec 5.
Ischemic stroke is one of major causes of disability. In the pathological process of ischemic stroke, the up-regulation of Ras homolog gene family, member A (RhoA) and its downstream effector, Ras homolog gene family (Rho)-associated coiled coil-containing kinase (ROCK), contribute to the neuroinflammation, blood-brain barrier (BBB) dysfunction, neuronal apoptosis, axon growth inhibition and astrogliosis. Accumulating evidences have revealed that hydrogen sulphide (HS) could reduce brain injury in animal model of ischemic stroke via inhibiting the RhoA/ROCK pathway. Recently, noncoding RNAs (ncRNAs) such as circular RNAs (circRNAs), long noncoding RNAs (lncRNAs) and microRNAs (miRNAs) have attracted much attention because of their essential role in adjusting gene expression both in physiological and pathological conditions. Numerous studies have uncovered the role of RhoA/ROCK pathway and ncRNAs in ischemic stroke. In this review, we focused on the role of HS, RhoA/ROCK pathway and ncRNAs in ischemic stroke and aimed to reveal new strategies for preventing and treating this devastating disease.
缺血性中风是导致残疾的主要原因之一。在缺血性中风的病理过程中，Ras同源基因家族成员A（RhoA）及其下游效应分子Ras同源基因家族（Rho）相关卷曲螺旋蛋白激酶（ROCK）的上调会导致神经炎症、血脑屏障（BBB）功能障碍、神经元凋亡、轴突生长抑制和星形胶质细胞增生。越来越多的证据表明，硫化氢（HS）可通过抑制RhoA/ROCK途径减轻缺血性中风动物模型中的脑损伤。近来，非编码RNA（ncRNA），如环状RNA（circRNA）、长链非编码RNA（lncRNA）和微小RNA（miRNA），因其在生理和病理条件下调节基因表达中的重要作用而备受关注。大量研究揭示了RhoA/ROCK途径和ncRNA在缺血性中风中的作用。在本综述中，我们重点关注HS、RhoA/ROCK途径和ncRNA在缺血性中风中的作用，旨在揭示预防和治疗这种毁灭性疾病的新策略。
