Ai Yong-Jian, He Meng-Qi, Wang Yi-Tao, Liang Qiong-Lin
Institute of Traditional Chinese Medicine-X, State Administration of Traditional Chinese Medicine Third-level Laboratory of Traditional Chinese Medicine Chemistry, Chinese Medicine Modernization Research Center, Tsinghua University Beijing 100084, China.
State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau Macau 999078, China.
Zhongguo Zhong Yao Za Zhi. 2022 Nov;47(21):5797-5805. doi: 10.19540/j.cnki.cjcmm.20220713.501.
Ulcerative colitis(UC) is a continuous inflammatory bowel disease with the main clinical manifestations of abdominal pain, diarrhea, and mucous bloody stools, mainly attacking the colorectal mucosa and submucosa. It is characterized by high recurrence rate, difficult cure, and clustering and regional occurrence. Chinese medicinal prescriptions for the treatment of UC have good therapeutic effect, multi-target regulation, slight toxicity, and no obvious side effects. In particular, the classical prescriptions highlight the characteristics and advantages of traditional Chinese medicine theory and have attracted much attention in recent years. To enable researchers to timely and comprehensively understand the classical prescriptions in the treatment of UC, we reviewed the studies about the pharmacodynamic material basis, quality control, action mechanism, and clinical application of relevant classical prescriptions. We first introduced the latest research progress in the active components such as alkaloids, polysaccharides, saponins, and flavonoids in relevant classical prescriptions. Then, we reviewed the latest research achievements on the quality control of classical prescriptions for the treatment of UC by gas chromatography, liquid chromatography, mass spectrometry, liquid chromatography-mass spectrometry and the like. Further, we summarized the research advances in the mechanisms of relevant prescriptions in the treatment of UC based on network pharmacology, molecular docking, integrated pharmacology platform, and animal experiments. Finally, we generalized the clinical application of the classical prescriptions for clearing heat and removing dampness, mildly regulating cold and heat, soothing liver and regulating spleen, strengthening spleen and invigorating Qi, and tonifying spleen and stomach. By systematic summary of the research progress in relevant classical prescriptions, we hope to promote the application and development of such prescriptions in UC treatment.
溃疡性结肠炎（UC）是一种连续性炎症性肠病，主要临床表现为腹痛、腹泻和黏液脓血便，主要侵犯结直肠黏膜和黏膜下层。其特点是复发率高、难以治愈，且呈聚集性和区域性发病。治疗UC的中药方剂具有良好的治疗效果、多靶点调节、毒性轻微且无明显副作用。特别是经典方剂突出了中医理论的特色和优势，近年来备受关注。为使研究人员及时、全面地了解经典方剂在UC治疗中的应用，我们综述了相关经典方剂的药效物质基础、质量控制、作用机制及临床应用等方面的研究。我们首先介绍了相关经典方剂中生物碱、多糖、皂苷、黄酮等活性成分的最新研究进展。然后，我们综述了采用气相色谱、液相色谱、质谱、液相色谱 - 质谱等方法对治疗UC的经典方剂进行质量控制的最新研究成果。进一步，我们基于网络药理学、分子对接、整合药理学平台及动物实验，总结了相关方剂治疗UC的作用机制研究进展。最后，我们概括了清热利湿、寒热平调、疏肝健脾、健脾益气、补脾健胃等经典方剂的临床应用。通过系统总结相关经典方剂的研究进展，我们希望推动此类方剂在UC治疗中的应用与发展。
