7T MRI 下纹状体动脉的 1D 与 3D 血流速度和搏动性测量。
1D versus 3D blood flow velocity and pulsatility measurements of lenticulostriate arteries at 7T MRI.
机构信息
Department of Radiology and Nuclear Medicine, Maastricht University Medical Center, PO Box 5800, 6202 AZ Maastricht, the Netherlands; School for Mental Health and Neuroscience, Maastricht University, PO Box 616, 6200 MD Maastricht, the Netherlands.
Department of Radiology and Nuclear Medicine, Maastricht University Medical Center, PO Box 5800, 6202 AZ Maastricht, the Netherlands; School for Mental Health and Neuroscience, Maastricht University, PO Box 616, 6200 MD Maastricht, the Netherlands; Department of Electrical Engineering, University of Eindhoven, PO Box 513, 5600 MB Eindhoven, the Netherlands.
出版信息
Magn Reson Imaging. 2023 Feb;96:144-150. doi: 10.1016/j.mri.2022.12.005. Epub 2022 Dec 5.
PURPOSE
7T MRI enables measurements of blood flow velocity waveforms in small, perforating cerebral arteries. As these vessels can be tortuous, acquisition methods sensitive to flow in only one direction may not be sufficient to accurately determine the dynamic blood flow velocity. In this study, we compared 1D with 3D velocity encoding to measure the blood flow velocity and pulsatility in the lenticulostriate arteries (LSAs).
METHODS
Blood flow velocity waveforms were measured in the LSAs of 18 subjects (age range: 20-74 years) using prospectively gated single-slice phase contrast (PC) MRI at 7T. For each subject, blood flow velocity waveforms were acquired in a single slice with one velocity encoding as well as three orthogonal velocity encodings. The peak velocity and pulsatility index (PI) were determined in the largest, perpendicularly planned LSA, one obliquely planned LSA and three smaller LSAs. The peak velocity and PI were compared between 1D and 3D measurements using Bland-Altman analysis, with the 95% limits of agreement (LOA) taken into account.
RESULTS
For the largest, perpendicularly planned LSA, the peak velocity was slightly lower (0.2 cm/s, 1.7%) for 1D compared to 3D measurements, with an LOA range from the mean difference of (-0.27;0.27). The PI was slightly higher (0.01, 1.6%) for the 1D measurement, and an LOA range from the mean difference in PI of (-0.045;0.045). The obliquely planned LSA and three smaller LSAs demonstrated larger deviations (range mean percentage difference: 3.9-8.2%).
CONCLUSION
1D velocity encoding using 2D PC MRI provides sufficiently accurate dynamic velocity and pulsatility measurements in slices perpendicularly planned to single, large LSAs compared to 3D velocity encoding, while increasing errors are obtained with obliquely planned slices. A greater error is indicated when measuring multiple (possibly tortuous or obliquely planned) smaller LSAs in one scan using one-directional single-slice PC MRI.
目的
7T MRI 能够测量小穿通脑动脉的血流速度波形。由于这些血管可能是迂曲的，因此仅对一个方向的血流敏感的采集方法可能不足以准确确定动态血流速度。在这项研究中，我们比较了 1D 和 3D 速度编码以测量纹状体动脉（LSAs）的血流速度和搏动指数。
方法
在 7T 下使用前瞻性门控单层面相位对比（PC）MRI，在 18 名受试者（年龄范围：20-74 岁）的 LSAs 中测量血流速度波形。对于每个受试者，使用一个速度编码和三个正交速度编码在单个切片中获取血流速度波形。在最大、垂直计划的 LSAs、一个斜计划的 LSAs 和三个较小的 LSAs 中确定峰值速度和搏动指数（PI）。使用 Bland-Altman 分析比较 1D 和 3D 测量的峰值速度和 PI，同时考虑到 95%一致性界限（LOA）。
结果
对于最大、垂直计划的 LSAs，1D 测量的峰值速度比 3D 测量低（0.2cm/s，1.7%），LOA 范围为（-0.27；0.27）。1D 测量的 PI 略高（0.01，1.6%），PI 的 LOA 范围为（-0.045；0.045）。斜计划的 LSAs 和三个较小的 LSAs 显示出更大的偏差（范围平均百分比差异：3.9-8.2%）。
结论
与 3D 速度编码相比，使用 2D PC MRI 的 1D 速度编码在垂直于单个大 LSAs 的切片中提供了足够准确的动态速度和搏动测量，而斜计划的切片则会增加误差。当在一次扫描中使用单向单层面 PC MRI 测量多个（可能是迂曲或斜计划）较小的 LSAs 时，误差更大。
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