Kilic Oguz, Buber Ipek, Kahraman Fatih
Department of Cardiology, Karaman Training and Research Hospital, Karaman, Turkey.
Department of Cardiology, Pamukkale University Hospitals, Denizli, Turkey.
J Coll Physicians Surg Pak. 2022 Dec;32(12):1519-1523. doi: 10.29271/jcpsp.2022.12.1519.
To investigate the usability of leuko-glycemic index (LGI) at chronic coronary syndromes (CCS) class 1 for determining the extent and severity of coronary artery disease (CAD).
An observational study.
Department of Cardiology, University of Pamukkale University Hospital, Turkey, between September 2021 and January 2022.
One hundred and thirty-four patients, whose myocardial perfusion scintigraphy (MPS) was requested due to CCS class 1, and on whom a coronary angiogram (CAG) was performed due to evidence of ischemia, were analysed. Blood samples were taken from the patients during their hospitalisation before CAG. LGI was calculated as mg/dl.mm3 by multiplying both values and dividing by a thousand. The patients were analysed in two groups according to the critical stenosis and non-critical stenosis detected in the coronary arteries.
The LGI was recorded as 480 mg/dl.mm3 (407-603) vs. 572 mg/dl.mm3 (433-877), p=0.006, and the Gensini score (6 (3-10) vs 40 (23-60), p<0.001) was significantly higher in the critical CAD group. A significant relationship has detected the increase in LGI and the extensity and severity of CAD (Unadjusted; OR (95% CI); 1.003 (1.001 - 1.004) p=0.002, adjusted; OR (95% CI); 1.002 (1.001 - 1.004) p=0.004).
A high LGI was a predictor of CAD severity among CCS class 1 patients and was found to correlate with the Gensini score. The use of this simple and inexpensive index, together with other non-invasive tests before CAG, may provide some knowledge about the severity of CAD.
Coronary artery disease, Leukocyte glucose index, Myocardial perfusion scintigraphy.
探讨白细胞血糖指数（LGI）在1级慢性冠状动脉综合征（CCS）中用于确定冠状动脉疾病（CAD）范围和严重程度的可用性。
一项观察性研究。
土耳其帕穆卡莱大学医院心脏病科，2021年9月至2022年1月。
分析134例因1级CCS而进行心肌灌注显像（MPS）且因缺血证据而接受冠状动脉造影（CAG）的患者。在患者住院期间、CAG检查前采集血样。LGI的计算方法是将两个值相乘再除以1000，单位为mg/dl.mm³。根据冠状动脉中检测到的临界狭窄和非临界狭窄情况将患者分为两组。
临界CAD组的LGI记录为480 mg/dl.mm³（407 - 603），而非临界CAD组为572 mg/dl.mm³（433 - 877），p = 0.006；Gensini评分（临界CAD组为6（3 - 10），非临界CAD组为40（23 - 60），p < 0.001）在临界CAD组显著更高。已检测到LGI升高与CAD的范围和严重程度之间存在显著关系（未调整；OR（95%CI）；1.003（1.001 - 1.004），p = 0.002，调整后；OR（95%CI）；1.002（1.001 - 1.004），p = 0.004）。
高LGI是1级CCS患者CAD严重程度的预测指标，且发现其与Gensini评分相关。在CAG检查前，将这个简单且廉价的指标与其他非侵入性检查一起使用，可能会提供一些关于CAD严重程度的信息。
冠状动脉疾病；白细胞葡萄糖指数；心肌灌注显像
