Aslan Nuray, Güneysu Fatih, Yürümez Yusuf, Güner Necip Gökhan, Akdeniz Sacit, Kaner Muharrem
Department of Emergency Medicine, Sakarya University Education and Research Hospital, Adapazarı, Turkey.
Department of Emergency Medicine, Sakarya University Faculty of Medicine, Adapazari, Turkey.
Med Sci Monit. 2025 Jan 31;31:e947156. doi: 10.12659/MSM.947156.
BACKGROUND The leuko-glycemic index (LGI) combines the white blood cell count and blood glucose levels and is calculated by multiplying the 2 values and dividing them by 1000. This study aimed to compare the prognostic value of the LGI in 199 patients with acute pulmonary embolism (APE) with and without diabetes mellitus. MATERIAL AND METHODS This study was conducted retrospectively on 199 patients who were admitted to the Emergency Department of Sakarya Training and Research Hospital between January 1, 2019, and December 31, 2022, and received a diagnosis of APE by pulmonary angiography. The patients were divided into 2 groups, diabetic and nondiabetic, based on their medical history. The groups were compared in terms of mortality according to the optimal cut-off value of LGI. RESULTS Of the 199 patients with APE included in the study, 61% were women and 39% were men. Mortality was higher in the diabetic group, and a simplified Pulmonary Embolism Severity Index score ≥1 was an independent predictor of all-cause mortality during the 30-day follow-up in the nondiabetic group (P=0.024). Multivariate logistic regression analysis showed that LGI was not an independent predictor of all-cause mortality during the first 30 days of follow-up in either group (P>0.05). CONCLUSIONS Mortality was higher in patients with diabetes and APE. However, the LGI was not an independent predictor of mortality in patients with or without diabetes. Since there are not enough studies on this subject, this result needs to be supported by additional research.
背景 白细胞血糖指数（LGI）结合了白细胞计数和血糖水平，通过将这两个值相乘并除以1000来计算。本研究旨在比较LGI在199例有或无糖尿病的急性肺栓塞（APE）患者中的预后价值。
材料与方法 本研究对2019年1月1日至2022年12月31日期间入住萨卡里亚培训与研究医院急诊科并通过肺血管造影确诊为APE的199例患者进行了回顾性研究。根据病史将患者分为糖尿病组和非糖尿病组。根据LGI的最佳临界值比较两组的死亡率。
结果 纳入研究的199例APE患者中，61%为女性，39%为男性。糖尿病组的死亡率更高，在非糖尿病组中，简化的肺栓塞严重程度指数评分≥1是30天随访期间全因死亡率的独立预测因素（P=0.024）。多因素逻辑回归分析显示，LGI在两组随访的前30天内均不是全因死亡率的独立预测因素（P>0.05）。
结论 糖尿病合并APE患者的死亡率更高。然而，LGI在有或无糖尿病患者中均不是死亡率的独立预测因素。由于关于该主题的研究不足，这一结果需要更多研究的支持。
