Nguyen T D, Scheving L A
Biochem Biophys Res Commun. 1987 Jun 15;145(2):884-7. doi: 10.1016/0006-291x(87)91047-3.
Thymosin alpha 1 has many effects on immune function and its absence in primary immunodeficiency states produce a clinical presentation similar to the one encountered in acquired immune deficiency syndrome (AIDS). Human immunodeficiency virus (HIV), the etiologic agent of AIDS, binds to T4 helper/inducer lymphocytes through specific surface receptors which include the CD4 glycoprotein. Octapeptide T, a component of the HIV envelope, mediates the binding of HIV to its receptor. In this report, we draw attention to the similarity between the amino acid sequence of thymosin alpha 1 and peptide T and its analogues. This similarity can produce a cross-reactivity between thymosin alpha 1 and HIV and may be a factor in the pathophysiology of the acquired immuno-deficiency syndrome.
胸腺素α1对免疫功能有多种作用，在原发性免疫缺陷状态下其缺失会产生类似于获得性免疫缺陷综合征（艾滋病）的临床表现。人类免疫缺陷病毒（HIV）是艾滋病的病原体，它通过包括CD4糖蛋白在内的特定表面受体与T4辅助/诱导淋巴细胞结合。八肽T是HIV包膜的一个成分，介导HIV与其受体的结合。在本报告中，我们提请注意胸腺素α1与肽T及其类似物氨基酸序列之间的相似性。这种相似性可能导致胸腺素α1与HIV之间产生交叉反应，并且可能是获得性免疫缺陷综合征病理生理学中的一个因素。
