Dhiman Kunal, Villemagne Victor L, Fowler Christopher, Bourgeat Pierrick, Li Qiao-Xin, Collins Steven, Rowe Christopher C, Masters Colin L, Ames David, Blennow Kaj, Zetterberg Henrik, Martins Ralph N, Gupta Veer
IMPACT - The Institute for Mental and Physical Health and Clinical Translation School of Medicine Deakin University Geelong Victoria Australia.
Western Health Partnership School of Nursing and Midwifery (Centre for Quality and Patient Safety Research in the Institute of Health Transformation) Faculty of Health Deakin University Melbourne Victoria Australia.
Alzheimers Dement (Amst). 2022 Dec 4;14(1):e12377. doi: 10.1002/dad2.12377. eCollection 2022.
Fatty acid-binding protein 3 (FABP3) is a biomarker of neuronal membrane disruption, associated with lipid dyshomeostasis-a notable Alzheimer's disease (AD) pathophysiological change. We assessed the association of cerebrospinal fluid (CSF) FABP3 levels with brain amyloidosis and the likelihood/risk of developing amyloidopathy in cognitively healthy individuals.
FABP3 levels were measured in CSF samples of cognitively healthy participants, > 60 years of age ( = 142), from the Australian Imaging, Biomarkers & Lifestyle Flagship Study of Ageing (AIBL).
FABP3 levels were positively associated with baseline brain amyloid beta (Aβ) load as measured by standardized uptake value ratio (SUVR, standardized = 0.22, .009) and predicted the change in brain Aβ load (standardized = 0.32, .004). Higher levels of CSF FABP3 (above median) were associated with a likelihood of amyloidopathy (odds ratio [OR] 2.28, 95% confidence interval [CI] 1.12 to 4.65, .023).
These results support inclusion of CSF FABP3 as a biomarker in risk-prediction models of AD.
脂肪酸结合蛋白3（FABP3）是神经元膜破坏的生物标志物，与脂质稳态失衡相关，脂质稳态失衡是阿尔茨海默病（AD）显著的病理生理变化。我们评估了脑脊液（CSF）中FABP3水平与脑淀粉样变性的关联，以及认知健康个体发生淀粉样病变的可能性/风险。
在澳大利亚衰老成像、生物标志物和生活方式旗舰研究（AIBL）中，对年龄大于60岁（n = 142）的认知健康参与者的脑脊液样本进行FABP3水平检测。
FABP3水平与通过标准化摄取值比率（SUVR）测量的基线脑淀粉样β蛋白（Aβ）负荷呈正相关（标准化β = 0.22，P = 0.009），并预测脑Aβ负荷的变化（标准化β = 0.32，P = 0.004）。脑脊液FABP3水平较高（高于中位数）与淀粉样病变的可能性相关（比值比[OR] 2.28，95%置信区间[CI] 1.12至4.65，P = 0.023）。
这些结果支持将脑脊液FABP3纳入AD风险预测模型中的生物标志物。
