在加纳猴子的小规模横断面血清学调查中，没有发现雅司病感染的证据。

No evidence for yaws infection in a small-scale cross-sectional serosurvey in Ghanaian monkeys.

机构信息

Department of Theoretical and Applied Biology, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.

Kumasi Centre for Collaborative Research in Tropical Medicine, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.

出版信息

Vet Med Sci. 2023 Jan;9(1):507-512. doi: 10.1002/vms3.1016. Epub 2022 Dec 8.

DOI:10.1002/vms3.1016

PMID:36480449

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9856988/

Abstract

BACKGROUND

Treponema pallidum (TP) is a spirochaete bacterium with subspecies that in humans cause syphilis (subsp. pallidum), bejel (subsp. endemicum) and yaws (subsp. pertenue; TPE). The latter is target for eradication which requires detailed information on yaws epidemiology. It has been shown that African nonhuman primates (NHPs) are infected with TPE strains that are closely related to the human infecting yaws bacterium. While human yaws infection is known to be endemic in Ghana, there is a paucity of information regarding TPE infection of Ghana's native NHPs.

OBJECTIVES

The objective was to perform a small-scale cross-sectional serological screening for antibodies against TPE in Ghanaian monkeys. Due to the reports of TPE-infected NHPs from neighbouring Côte d'Ivore, we hypothesised that monkeys in Ghana are infected with TPE and, therefore, are seropositive for antibodies against-Treponema.

METHODS

We sampled blood from 37 NHPs representing four species: Erythrocebus patas (16/37) 43.2%, Papio anubis (15/37) 40.5%, Chlorocebus sabaeus (3/37) 8.1% and Cercopithecus mona (3/37) 8.1%. Samples were tested using the NHP validated treponemal test ESPLINE TP.

RESULTS

All 37 animals were seronegative for yaws infection.

CONCLUSIONS

We cannot exclude yaws infection in NHPs in Ghana at this point. Our study, in combination with the absence of reports of clinically infected NHPs in a yaws endemic country is, however, supportive for the current thinking that interspecies infection with TPE is extremely rare. This is an important finding for the current ongoing yaws eradication campaign.

摘要

背景

苍白密螺旋体（TP）是一种螺旋体细菌，其亚种在人类中引起梅毒（亚种。苍白）、贝杰尔（亚种。地方性）和雅司病（亚种。珀滕努；TPE）。后者是根除的目标，这需要详细了解雅司病的流行病学信息。已经表明，非洲非人灵长类动物（NHPs）感染了与引起人类雅司病的细菌密切相关的 TPE 株。虽然已知人类雅司病在加纳流行，但关于加纳本地 NHP 感染 TPE 的信息很少。

目的

本研究旨在对加纳猴子进行 TPE 抗体的小型横断面血清学筛查。由于有报道称来自邻国科特迪瓦的 TPE 感染的 NHPs，我们假设加纳的猴子感染了 TPE，因此对-Treponema 的抗体呈血清阳性。

方法

我们从代表四个物种的 37 只 NHPs 中抽取血液：Erythrocebus patas（16/37）占 43.2%、Papio anubis（15/37）占 40.5%、Chlorocebus sabaeus（3/37）占 8.1%和 Cercopithecus mona（3/37）占 8.1%。使用经过验证的 NHP 梅毒试验 ESPLINE TP 对样本进行检测。