Emerg Infect Dis. 2018 Jun;24(6):1002-1009. doi: 10.3201/eid2406.180037.
We investigated Treponema pallidum infection in 8 nonhuman primate species (289 animals) in Tanzania during 2015-2017. We used a serologic treponemal test to detect antibodies against the bacterium. Infection was further confirmed from tissue samples of skin-ulcerated animals by 3 independent PCRs (polA, tp47, and TP_0619). Our findings indicate that T. pallidum infection is geographically widespread in Tanzania and occurs in several species (olive baboons, yellow baboons, vervet monkeys, and blue monkeys). We found the bacterium at 11 of 14 investigated geographic locations. Anogenital ulceration was the most common clinical manifestation; orofacial lesions also were observed. Molecular data show that nonhuman primates in Tanzania are most likely infected with T. pallidum subsp. pertenue-like strains, which could have implications for human yaws eradication.
我们在 2015 年至 2017 年期间调查了坦桑尼亚的 8 种非人类灵长类动物物种（289 只动物）中的梅毒螺旋体感染情况。我们使用血清学梅毒螺旋体检测来检测针对该细菌的抗体。进一步通过 3 种独立的 PCR（polA、tp47 和 TP_0619）从皮肤溃疡动物的组织样本中确认感染。我们的研究结果表明，梅毒螺旋体感染在坦桑尼亚具有广泛的地理分布，并发生在几个物种（橄榄狒狒、黄狒狒、长尾猴和蓝猴）中。我们在 14 个调查的地理位置中的 11 个发现了该细菌。生殖器溃疡是最常见的临床表现；还观察到口腔病变。分子数据表明，坦桑尼亚的非人类灵长类动物最有可能感染类似于梅毒螺旋体亚种。苍白亚种的菌株，这可能对人类雅司病的根除产生影响。
