南海软珊瑚 Sarcophyton ehrenbergi 中进一步未描述的海松烷类化合物：结构阐明和生物评价。

Further undescribed cembranoids from South China Sea soft coral Sarcophyton ehrenbergi: Structural elucidation and biological evaluation.

机构信息

Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals and College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou, 310014, China; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Zhangjiang Hi-Tech Park, Shanghai, 201203, China.

College of Pharmacy, Guangdong Medical University, Zhanjiang, Guangdong, 524023, PR China; Shandong Laboratory of Yantai Drug Discovery, Bohai Rim Advanced Research Institute for Drug Discovery, Yantai, Shandong, 264117, China.

出版信息

Phytochemistry. 2023 Feb;206:113549. doi: 10.1016/j.phytochem.2022.113549. Epub 2022 Dec 5.

DOI:10.1016/j.phytochem.2022.113549

PMID:36481314

Abstract

A detailed chemical investigation of the South China Sea soft coral Sarcophyton ehrenbergi has yield seven undescribed cembranoids, namely isoehrenbergol D and sarcoehrenolides F-K embodying a rare α,β-unsaturated-lactone moiety at C-6 to C-19, along with two known related compounds, ehrenbergol D and sarcoehrenolide A. Their structures and absolute configurations were unambiguously established in the light of extensive spectroscopic data analysis, modified Mosher's method, X-ray diffraction analysis, and quantum chemical computation method. In a bioassay for α-glucosidase inhibition, ehrenbergol D was evaluated as α-glucosidase inhibitor with an IC value of 13.57 μM.

摘要

对南海软珊瑚 Sarcophyton ehrenbergi 的详细化学研究得到了七个未被描述的海松烷类化合物，即 isoehrenbergol D 和 sarcoehrenolides F-K，它们在 C-6 到 C-19 处含有罕见的α,β-不饱和内酯部分，以及两种已知的相关化合物 ehrenbergol D 和 sarcoehrenolide A。根据广泛的光谱数据分析、改良的 Mosher 法、X 射线衍射分析和量子化学计算方法，明确确定了它们的结构和绝对构型。在α-葡萄糖苷酶抑制的生物测定中，ehrenbergol D 被评估为具有 IC 值为 13.57 μM 的α-葡萄糖苷酶抑制剂。