State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.
College of Material Science and Engineering, Central South University of Forestry and Technology, Changsha 410004, China.
Sci Rep. 2017 Apr 21;7:46584. doi: 10.1038/srep46584.
Nine new bicyclic cembranoids, sarcophytrols M-U(1-9), were isolated from the South China Sea soft coral Sarcophyton trocheliophorum as minor components, along with one known related cembranoid 10. Their structures were elucidated by detailed spectroscopic analysis and chemical conversion. The chemical structures of these metabolites are characterized by the different patterns of the additional cyclization within the 14-member skeleton, which leading to the formation of furan, pyran, oxepane, and peroxyl rings, respectively. Among them, sarcophytrols R and S(6 and 7) share a rare decaryiol skeleton with an unusual C12/C15 cyclization. In addition, the absolute configurations of sarcophytrols M and T(1 and 8) were determined by the modified Mosher's method. The research of these new secondary metabolites provided a further understanding of the diversity of cyclized cembranoids from the title species.
从南海软珊瑚 Sarcophyton trocheliophorum 中分离到了 9 种新的二环海松烷类化合物 sarcophytrols M-U(1-9)，它们是作为次要成分存在的，此外还有一种已知的相关海松烷类化合物 10。通过详细的光谱分析和化学转化，确定了它们的结构。这些代谢物的化学结构的特点是在 14 元骨架内的附加环化模式不同，分别形成呋喃、吡喃、环氧丙烷和过氧环。其中，sarcophytrols R 和 S(6 和 7) 具有罕见的 decaryiol 骨架，其 C12/C15 环化方式不同。此外，通过改进的 Mosher 法确定了 sarcophytrols M 和 T(1 和 8) 的绝对构型。对这些新的次生代谢产物的研究进一步了解了该种软珊瑚中环化海松烷类化合物的多样性。
