Li Wei, Zou Yi-Hong, Ge Man-Xi, Lou Lan-Lan, Xu Yun-Shao, Ahmed Abrar, Chen Yun-Yun, Zhang Jun-Sheng, Tang Gui-Hua, Yin Sheng
School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China.
Mar Drugs. 2017 Mar 23;15(4):85. doi: 10.3390/md15040085.
Two novel biscembranoids, sarelengans A and B ( and ), five new cembranoids, sarelengans C-G (-), along with two known cembranoids ( and ) were isolated from the South China Sea soft coral . Their structures were determined by spectroscopic and chemical methods, and those of , , , and were confirmed by single crystal X-ray diffraction. Compounds and represent the first example of biscembranoids featuring a -fused A/B-ring conjunction between the two cembranoid units. Their unique structures may shed light on an unusual biosynthetic pathway involving a cembranoid-∆⁸ rather than the normal cembranoid-∆¹ unit in the -Diels-Alder cycloaddition. Compounds and exhibited potential inhibitory effects on nitric oxide production in RAW 264.7 macrophages, with IC values being at 18.2 and 32.5 μM, respectively.
从中国南海软珊瑚中分离出了两种新型双柏烷类化合物，sarelengans A和B（以及），五种新的柏烷类化合物，sarelengans C-G（-），以及两种已知的柏烷类化合物（和）。通过光谱和化学方法确定了它们的结构，并且通过单晶X射线衍射证实了、、、和的结构。化合物和代表了双柏烷类化合物的首个例子，其在两个柏烷类单元之间具有一个稠合的A/B环连接。它们独特的结构可能为一条不寻常的生物合成途径提供线索，该途径涉及在狄尔斯-阿尔德环加成反应中是柏烷类-Δ⁸而非正常的柏烷类-Δ¹单元。化合物和对RAW 264.7巨噬细胞中一氧化氮的产生表现出潜在的抑制作用，IC值分别为18.2和32.5 μM。
