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超声 MEMS 收发器用于血糖感测的实验和概率模型验证。

Experimental and probabilistic model validation of ultrasonic MEMS transceiver for blood glucose sensing.

机构信息

Semiconductor Research Laboratory, Faculty of Engineering and Technology (ITER), Siksha 'O' Anusandhan (Deemed to be University), Bhubaneswar, 751030, India.

School of Biological Science, Biomedical Engineering, University of Reading, Whiteknights, RG6 6AY, UK.

出版信息

Sci Rep. 2022 Dec 8;12(1):21259. doi: 10.1038/s41598-022-25717-x.

Abstract

In contrast to traditional laboratory glucose monitoring, recent developments have focused on blood glucose self-monitoring and providing patients with a self-monitoring device. This paper proposes a system based on ultrasound principles for quantifying glucose levels in blood by conducting an in-vitro experiment with goat blood before human blood. The ultrasonic transceiver is powered by a frequency generator that operates at 40 kHz and 1.6 V, and variations in glucose level affect the ultrasonic transceiver readings. The RVM probabilistic model is used to determine the variation in glucose levels in a blood sample. Blood glucose levels are measured simultaneously using a commercial glucose metre for confirmation. The experimental data values proposed are highly correlated with commercial glucose metre readings. The proposed ultrasonic MEMS-based blood glucometer measures a glucose level of [Formula: see text] mg/dl. In the near future, the miniature version of the experimental model may be useful to human society.

摘要

与传统的实验室血糖监测相比,最近的发展集中在血糖自我监测上,并为患者提供自我监测设备。本文提出了一种基于超声原理的系统,通过在进行人体血液实验之前使用山羊血液进行体外实验来定量血液中的血糖水平。超声收发器由工作频率为 40 kHz 和 1.6 V 的频率发生器供电,血糖水平的变化会影响超声收发器的读数。使用 RVM 概率模型来确定血样中葡萄糖水平的变化。同时使用商业血糖仪测量血糖水平以进行确认。所提出的实验数据值与商业血糖仪读数高度相关。所提出的基于超声微机电系统的血糖仪可测量[Formula: see text]mg/dl 的血糖水平。在不久的将来,实验模型的微型版本可能对人类社会有用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11b6/9732296/dfcccf103937/41598_2022_25717_Fig1_HTML.jpg

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