Wang Yi, Wen Huaichang, Wang Mengli, Lu Meijing
Department of Anesthesiology, First Affiliated Hospital of Wannan Medical College, No. 2 Zhe Shan Street, Wuhu, 241000, Anhui, China.
Pain Ther. 2023 Feb;12(1):81-92. doi: 10.1007/s40122-022-00463-0. Epub 2022 Dec 8.
Patients with hip surgery often experience moderate to severe postoperative pain, and need large doses of opioids to relieve it, which is not conducive to patient rehabilitation. Pericapsular nerve group (PENG) block is a new regional block technique that is considered to reduce postoperative pain and the use of opioids. The purpose of this study was to evaluate the efficacy and safety of PENG block for postoperative analgesia after hip surgery.
We searched multiple databases for randomized controlled trials (RCTs) published in English, which compared PENG block with fascia iliaca compartment block (FICB). The primary outcome was 24 h postsurgical opioid consumption (OC). The secondary outcomes were pain scores (PSs) at different timepoints after surgery and the incidence of postoperative nausea and vomiting (PONV).
Five RCTs involving 234 patients were selected for our analysis. Our results show that the 24 h OC was drastically lower in PENG block versus FICB patients (SMD -0.60, 95% CI -1.08 to -0.11); P < 0.05, I = 69%). At the same time, there were no significant difference in postsurgical PSs between the two cohorts (6 h: MD -0.07, 95% CI -0.67 to 0.53; P = 0.82, I = 43%; 12 h: MD -0.60, 95% CI -1.40 to 0.19; P = 0.14, I = 31%; 24 h: MD 0.17, 95% CI -0.87 to 1.21; P = 0.75, I = 76%; 36 h: MD 0.80, 95% CI -0.92 to 2.51; P = 0.36, I = 73%; 48 h: MD -0.06, 95% CI -0.75 to 0.63; P = 0.86, I = 0%) and the incidence of PONV (RR 1.00, 95% CI 0.40-2.50, P = 1.00, I = 35%).
Our research shows that PENG block can reduce the use of opioids after hip surgery and is effective in postoperative analgesia. Future research should explore the injection method, concentration, and dosage.
髋关节手术患者术后常经历中度至重度疼痛,需要大剂量阿片类药物来缓解,这不利于患者康复。关节囊周围神经组(PENG)阻滞是一种新的区域阻滞技术,被认为可减轻术后疼痛并减少阿片类药物的使用。本研究的目的是评估PENG阻滞用于髋关节手术后镇痛的有效性和安全性。
我们检索了多个数据库,查找以英文发表的随机对照试验(RCT),这些试验比较了PENG阻滞与髂筋膜间隙阻滞(FICB)。主要结局是术后24小时阿片类药物消耗量(OC)。次要结局是术后不同时间点的疼痛评分(PS)以及术后恶心呕吐(PONV)的发生率。
我们选择了5项涉及234例患者的RCT进行分析。我们的结果显示,与FICB患者相比,PENG阻滞患者的24小时OC显著更低(标准化均数差 -0.60,95%置信区间 -1.08至 -0.11);P < 0.05,I² = 69%)。同时,两组患者术后PS在各时间点均无显著差异(6小时:平均差 -0.07,95%置信区间 -0.67至0.53;P = 0.82,I² = 43%;12小时:平均差 -0.60,95%置信区间 -1.40至0.19;P = 0.14,I² = 31%;24小时:平均差0.17,95%置信区间 -0.87至1.21;P = 0.75,I² = 76%;36小时:平均差0.80,95%置信区间 -0.92至2.51;P = 0.36,I² = 73%;48小时:平均差 -0.06,95%置信区间 -0.75至0.63;P = 0.86,I² = 0%),且PONV发生率也无显著差异(风险比1.00,95%置信区间0.40 - 2.50,P = 1.00,I² = 35%)。
我们的研究表明,PENG阻滞可减少髋关节手术后阿片类药物的使用,且在术后镇痛方面有效。未来的研究应探索注射方法、浓度和剂量。