Acupuncture and Moxibustion Academy, Changchun University of Chinese Medicine, Changchun, China.
Northeast Asian Institute of Traditional Chinese Medicine, Changchun University of Chinese Medicine, Changchun, China.
Medicine (Baltimore). 2022 Dec 2;101(48):e32163. doi: 10.1097/MD.0000000000032163.
Crohn's disease (CD) is a chronic recurrent gastrointestinal disorder with a high incidence of inflammation due to intestinal inflammation. Acupuncture is commonly used as an alternative therapy for patients with CD. The aim of this study was to design a systematic review and meta-analysis protocol, to provide guidance for the establishment of systematic evaluation and meta-analysis on the efficacy and safety of acupuncture on CD.
We will search PubMed, the Cochrane Library, Embase, Web of Science, and 4 Chinese databases: China National Knowledge Infrastructure (CNKI), Wanfang database, VIP database, and Chinese Biomedical Database to obtain randomized controlled trials of CD treated with acupuncture from inception to November 5, 2022. Primary outcome include CD symptoms severity and clinical efficacy, secondary outcome indicators include laboratory indicators or inflammatory markers, severity of endoscopic lesions, quality of life, and safety outcomes. We will analyze the data using RevMan V.5.4 software. Two reviewers will assess the risk of bias and study quality by the Cochrane Collaboration Risk of Bias Tool and GRADE methods, respectively.
This systematic review and meta-analysis protocol will analyze the efficacy, symptom improvement, quality of life, and safety of acupuncture therapy for CD.
This protocol outlines the planned scope and methodology of a forthcoming systematic review and meta-analysis to provide guidelines for a rigorous assessment of the efficacy and safety of acupuncture for the treatment of CD.
克罗恩病（CD）是一种慢性复发性胃肠道疾病，由于肠道炎症，其炎症发生率较高。针灸常被用作 CD 患者的替代疗法。本研究旨在设计一个系统评价和荟萃分析方案，为针灸治疗 CD 的疗效和安全性的系统评价和荟萃分析的建立提供指导。
我们将检索 PubMed、Cochrane 图书馆、Embase、Web of Science 和 4 个中文数据库：中国知网（CNKI）、万方数据库、维普数据库和中国生物医学数据库，以获取 2022 年 11 月 5 日之前针灸治疗 CD 的随机对照试验。主要结局包括 CD 症状严重程度和临床疗效，次要结局指标包括实验室指标或炎症标志物、内镜病变严重程度、生活质量和安全性结局。我们将使用 RevMan V.5.4 软件分析数据。两位审查员将分别使用 Cochrane 协作风险偏倚工具和 GRADE 方法评估风险偏倚和研究质量。
本系统评价和荟萃分析方案将分析针灸治疗 CD 的疗效、症状改善、生活质量和安全性。
本方案概述了即将进行的系统评价和荟萃分析的计划范围和方法，为针灸治疗 CD 的疗效和安全性的严格评估提供了指导。
