Changchun University of Chinese Medicine, Nanguan District, Changchun, Jilin, China.
Medicine (Baltimore). 2021 May 28;100(21):e26043. doi: 10.1097/MD.0000000000026043.
T2DM with NAFLD is a common disorder of glucose and lipid metabolism affecting the quality of life of patients. Due to the limitations and adverse reactions of drug treatment, acupuncture has been proved to be an effective method for the treatment of T2DM with NAFLD. This study aims to evaluate the efficacy and safety of acupuncture in the treatment of NAFLD in T2DM class, and to provide high-quality evidence for acupuncture in the treatment of this disease.
From establishment of the database to 31 July 2021, We will search the Cochrane Central Register of controlled trials, PubMed, MEDLINE, EMBASE, Web of science. Five Chinese databases, including China National Knowledge Infrastructure (CNKI), WanFang database, VIP, Chinese Biomedical Literature Database (CBM) and the Chinese clinical trial registry. There are no restrictions on language or publication, and they are independently screened and collected by two reviewers. Review Manager 5.3 software will be used for meta analysis. If necessary, heterogeneity testing, data synthesis, and subgroup analysis will be performed.
The effectiveness and safety of acupuncture in the treatment of T2DM with NAFLD will be assessed by the outcomes of test's, including: imaging indicators, biomarkers of hepatic steatosis, serological indicators of hepatic fibrosis, improvement of serum NAFLD liver fat score, BMI, blood glucose indexes, blood lipid indexes, insulin level and safety indicators.
This meta-analysis will further determine the beneficial efficacy and safety of acupuncture for T2DM combined with NAFLD.
伴有非酒精性脂肪性肝病的 2 型糖尿病是一种常见的糖脂代谢紊乱疾病，影响患者的生活质量。由于药物治疗的局限性和不良反应，针灸已被证明是治疗伴有非酒精性脂肪性肝病的 2 型糖尿病的有效方法。本研究旨在评估针灸治疗非酒精性脂肪性肝病 2 型糖尿病的疗效和安全性，为针灸治疗该病提供高质量的证据。
从数据库建立到 2021 年 7 月 31 日，我们将检索 Cochrane 中央对照试验注册库、PubMed、MEDLINE、EMBASE、Web of Science。五个中文数据库，包括中国国家知识基础设施（CNKI）、万方数据库、VIP、中国生物医学文献数据库（CBM）和中国临床试验注册中心。不限制语言或出版，由两名评审员独立筛选和收集。使用 Review Manager 5.3 软件进行荟萃分析。如有必要，将进行异质性检验、数据综合和亚组分析。
将通过测试结果评估针灸治疗 2 型糖尿病合并非酒精性脂肪性肝病的疗效和安全性，包括：影像学指标、肝脂肪变性生物标志物、肝纤维化血清学指标、血清非酒精性脂肪性肝病肝脂肪评分、BMI、血糖指标、血脂指标、胰岛素水平和安全性指标的改善。
本荟萃分析将进一步确定针灸治疗 2 型糖尿病合并非酒精性脂肪性肝病的有益疗效和安全性。
