Zhang Meiyu, Li Lei, Lei Lecheng, Kang Kang, Xiao Chengliang
College of Chemical and Biological Engineering, Zhejiang University, Hangzhou310027, China.
Institute of Zhejiang University─Quzhou, 78 Jiuhua Boulevard North, Quzhou324000, China.
ACS Appl Mater Interfaces. 2022 Dec 21;14(50):55354-55364. doi: 10.1021/acsami.2c15864. Epub 2022 Dec 9.
In the field of replacement of conventional dialysis treatment, searching superior materials for removal of protein-bound uremic toxins is a challenge on account of strong interactions between proteins and uremic toxins. Herein, we first adopted cationic metal-organic frameworks (MOFs), ZJU-X6 and ZJU-X7, as sorbents to decontaminate uremic toxins (-cresyl sulfate and indoxyl sulfate). ZJU-X6 and ZJU-X7 exhibited innate advantage for sequestration of uremic toxins by utilizing a positive charge framework with exchangeable anions. Especially, ZJU-X6 showed a higher sorption capacity and faster sorption kinetics than those of most reported materials. Moreover, the cationic MOF materials could selectively remove uremic toxins even if in the presence of competitive chloride ions and proteins. Meanwhile, pair distribution function (PDF) and density functional theory (DFT) were employed to elucidate the sorption mechanism between uremic toxins and sorbents. This work suggests an attractive avenue for constructing new types of sorbents to eliminate uremic toxins for uremia treatment.
在传统透析治疗的替代领域，由于蛋白质与尿毒症毒素之间存在强烈相互作用，寻找用于去除与蛋白质结合的尿毒症毒素的优质材料是一项挑战。在此，我们首次采用阳离子金属有机框架材料（MOFs）ZJU-X6和ZJU-X7作为吸附剂来净化尿毒症毒素（对甲酚硫酸盐和硫酸吲哚酚）。ZJU-X6和ZJU-X7通过利用带有可交换阴离子的正电荷框架，在螯合尿毒症毒素方面展现出固有优势。特别是，ZJU-X6比大多数已报道的材料表现出更高的吸附容量和更快的吸附动力学。此外，即使存在竞争性氯离子和蛋白质，阳离子MOF材料也能选择性地去除尿毒症毒素。同时，采用对分布函数（PDF）和密度泛函理论（DFT）来阐明尿毒症毒素与吸附剂之间的吸附机制。这项工作为构建新型吸附剂以消除尿毒症毒素用于尿毒症治疗提供了一条有吸引力的途径。
