Department of Nephrology, Dialysis, and Transplantation, Sahloul University Hospital, Sousse, Tunisia.
Department of Pathology, Farhat Hached University Hospital Sousse, Sousse, Tunisia.
Am J Mens Health. 2022 Nov-Dec;16(6):15579883221139914. doi: 10.1177/15579883221139914.
Acute interstitial nephritis (AIN) is a relevant cause of acute renal failure. Drugs are the predominant cause, followed by infections and idiopathic lesions. AIN, as a form of hypersensitivity reaction, is an uncommon manifestation in the setting of human parasitic infections. We report a case of a polyparasitic infection (, and ) resulting in a severe biopsy-proven AIN in a 61-year-old male patient. Despite the antiparasitic treatment followed by corticosteroid therapy, and during the 6-month follow-up period, the patient remained dialysis-dependent, and he developed autoimmune hemolytic anemia. Extensive search for another infection or neoplasia was negative. Immunological tests were also negative. The resulting hypersensitivity reaction to the triple parasite infection would have led to fatal evolution for the kidneys affected by this unusual type of AIN.
急性间质性肾炎（AIN）是急性肾衰竭的一个重要原因。药物是主要原因，其次是感染和特发性病变。AIN 作为一种超敏反应，在人类寄生虫感染的情况下并不常见。我们报告了一例多寄生虫感染（、和）导致 61 岁男性患者严重活检证实的 AIN 的病例。尽管进行了抗寄生虫治疗和随后的皮质类固醇治疗，但在 6 个月的随访期间，患者仍依赖透析，并发生自身免疫性溶血性贫血。广泛寻找其他感染或肿瘤均为阴性。免疫性检查也为阴性。这种三重寄生虫感染引起的超敏反应可能导致受这种不寻常类型的 AIN 影响的肾脏发生致命性演变。
