Zhang Songya, Chen Yunliang, Zhu Jing, Lu Qiujie, Cryle Max J, Zhang Youming, Yan Fu
CAS Key Laboratory of Quantitative Engineering Biology, Shenzhen Institute of Synthetic Biology, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China.
Helmholtz International Lab for Anti-Infectives, Shandong University-Helmholtz Institute of Biotechnology, State Key Laboratory of Microbial Technology, Shandong University, Qingdao, Shandong 266237, China.
Nat Prod Rep. 2023 Mar 22;40(3):557-594. doi: 10.1039/d2np00044j.
Covering: up to 2022 are ubiquitous in terrestrial and marine environments, where they display a fascinating metabolic diversity. As a result, these bacteria are a prolific source of active natural products. One important class of these natural products is the nonribosomal lipopeptides, which have diverse biological activities and play important roles in the lifestyle of . The importance of this class is highlighted by the use of related antibiotics in the clinic, such as daptomycin (tradename Cubicin). By virtue of recent advances spanning chemistry and biology, significant progress has been made in biosynthetic studies on the lipopeptide antibiotics produced by . This review will serve as a comprehensive guide for researchers working in this multidisciplinary field, providing a summary of recent progress regarding the investigation of lipopeptides from . In particular, we highlight the structures, properties, biosynthetic mechanisms, chemical and chemoenzymatic synthesis, and biological functions of lipopeptides. In addition, the application of genome mining techniques to that have led to the discovery of many novel lipopeptides is discussed, further demonstrating the potential of lipopeptides from for future development in modern medicine.
截至2022年，（相关内容）在陆地和海洋环境中无处不在，在这些环境中它们展现出迷人的代谢多样性。因此，这些细菌是活性天然产物的丰富来源。这些天然产物的一个重要类别是非核糖体脂肽，其具有多样的生物活性，并在（某生物）的生活方式中发挥重要作用。临床中使用相关抗生素（如达托霉素，商品名 Cubicin）突出了这类物质的重要性。凭借化学和生物学领域的最新进展，在（某生物）产生的脂肽抗生素的生物合成研究方面取得了重大进展。本综述将为在这个多学科领域工作的研究人员提供全面指南，总结关于（某生物）来源的脂肽研究的最新进展。特别是，我们重点介绍脂肽的结构、性质、生物合成机制、化学合成和化学酶促合成以及生物学功能。此外，还讨论了基因组挖掘技术在（某生物）上的应用，这些应用导致发现了许多新型脂肽，进一步证明了（某生物）来源的脂肽在现代医学未来发展中的潜力。
