Faculty 7: Natural and Environmental Sciences, Institute for Environmental Sciences, University Koblenz Landau, Fortstraße 7, 76829 Landau, Germany.
Junior Research Group Chemistry of Microbial Communication, Leibniz Institute for Natural Product Research and Infection Biology Hans Knöll Institute (HKI), Beutenbergstraße 11a, 07745 Jena, Germany.
Nat Prod Rep. 2020 Jan 1;37(1):29-54. doi: 10.1039/c9np00022d. Epub 2019 Aug 22.
Bacteria of the genus Pseudomonas are ubiquitous in nature. Pseudomonads display a fascinating metabolic diversity, which correlates with their ability to colonize an extremely wide range of ecological niches. As a result, these bacteria are a prolific source of natural products. Biosynthesis of the latter is often orchestrated by arrays of chemical signals arising from intraspecies communication or interspecies relationships with bacteria, fungi, amoebae, plants, and insects. Especially nonribosomal lipopeptides, which have diverse biological activities, play important roles in the lifestyle of pseudomonads. In this review, we will focus on the molecular structures, properties, biosynthetic pathways, and biological functions of pseudomonal lipopeptides. This review is not only addressed to bio/chemists rather it serves as a comprehensive guide for all researchers (micro/biologists, ecologists, and environmental scientists) working in this multidisciplinary field.
假单胞菌属的细菌在自然界中无处不在。假单胞菌表现出令人着迷的代谢多样性，这与其能够定殖极其广泛的生态位的能力相关。因此，这些细菌是天然产物的丰富来源。后者的生物合成通常由来自种内交流或与细菌、真菌、变形虫、植物和昆虫的种间关系的化学信号的排列来协调。特别是具有多种生物活性的非核糖体脂肽，在假单胞菌的生活方式中起着重要作用。在这篇综述中，我们将重点介绍假单胞菌脂肽的分子结构、特性、生物合成途径和生物学功能。这篇综述不仅针对生物/化学家，也为所有在这个多学科领域工作的研究人员（微生物学家、生态学家和环境科学家）提供了全面的指南。
