Department of Diagnostic Pathology, Nara Medical University, Kashihara, Japan.
Department of Clinical Technology, Yamatotakada Municipal Hospital, Yamatotakada, Japan.
Diagn Cytopathol. 2023 Mar;51(3):E98-E104. doi: 10.1002/dc.25088. Epub 2022 Dec 9.
Here, we report an extremely rare case of carcinoma with thymus-like differentiation (CASTLE) of the parotid gland. CASTLE is a rare malignant epithelial tumor with thymic epithelial differentiation that arises in the thyroid gland or perithyroidal soft tissue. CASTLE of salivary gland origin is rare, with only nine published case reports to date (reported as "CASTLE" or "thymic carcinoma"). It is critical to diagnose salivary gland tumors using fine needle aspiration cytology. However, this tumor is rare, and there have been few studies on its cytomorphological features. Therefore, it is important to understand the cytological diagnostic characteristics of CASTLE. Herein, we review the cytological features and diagnostic characteristics of salivary gland CASTLE. We also report the genotype results obtained using targeted exome sequencing, which we analyzed with DNA extracted from formalin-fixed paraffin-embedded tissue.
在这里，我们报告了一例极为罕见的腮腺伴胸腺样分化癌（CASTLE）。CASTLE 是一种罕见的恶性上皮肿瘤，具有胸腺样上皮分化，发生于甲状腺或甲状腺周围软组织。涎腺来源的 CASTLE 很少见，迄今为止仅有 9 例已发表的病例报告（报告为“CASTLE”或“胸腺癌”）。使用细针抽吸细胞学诊断涎腺肿瘤至关重要。然而，这种肿瘤很少见，对其细胞形态学特征的研究也很少。因此，了解 CASTLE 的细胞学诊断特征很重要。在此，我们回顾了涎腺 CASTLE 的细胞学特征和诊断特征。我们还报告了使用福尔马林固定石蜡包埋组织提取的 DNA 进行靶向外显子组测序获得的基因型结果。
