链球菌蛋白T诱导超延迟超敏反应和淋巴细胞刺激。
Streptococcal protein T induced hyperdelayed sensitivity and lymphocyte stimulation.
作者信息
Ludwicka A, Ziemba-Zołtowska B
出版信息
Zentralbl Bakteriol Orig A. 1978 Sep;241(3):286-93.
PMID:364882
Abstract
T protein was isolated from Streptococcus pyogenes types 1 and 12 by application CNBr-sepharose-trypsin and purified by ion exchange chromatography. It was indicated that purified T1 and T12 proteins have lymphocyte transforming activity. It was also observed that T12 protein induces immediate and delayed type hypersensitivity in guinea pigs previously sensitized with T12 antigen emulsified with complete FREUND's adjuvant.
摘要
通过应用溴化氰-琼脂糖-胰蛋白酶从1型和12型化脓性链球菌中分离出T蛋白，并通过离子交换色谱法进行纯化。结果表明，纯化的T1和T12蛋白具有淋巴细胞转化活性。还观察到，T12蛋白能在先前用完全弗氏佐剂乳化的T12抗原致敏的豚鼠中诱导速发型和迟发型超敏反应。
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