Department of Microbiology and Molecular Genetics and the Center for Vaccine Research, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Department of Medicine, Center for Emerging Pathogens, Public Health Research Institute, New Jersey Medical School, Rutgers University, Newark, NJ, USA.
Cell. 2022 Dec 8;185(25):4682-4702. doi: 10.1016/j.cell.2022.10.025.
Despite having been identified as the organism that causes tuberculosis in 1882, Mycobacterium tuberculosis has managed to still evade our understanding of the protective immune response against it, defying the development of an effective vaccine. Technology and novel experimental models have revealed much new knowledge, particularly with respect to the heterogeneity of the bacillus and the host response. This review focuses on certain immunological elements that have recently yielded exciting data and highlights the importance of taking a holistic approach to understanding the interaction of M. tuberculosis with the many host cells that contribute to the development of protective immunity.
尽管 1882 年就已经确定分枝杆菌是引起结核病的病原体，但我们仍然未能完全了解针对它的保护性免疫反应，这也使得有效疫苗的研发受阻。技术和新型实验模型揭示了许多新知识，尤其是针对杆菌的异质性和宿主反应。这篇综述重点介绍了最近获得令人兴奋数据的某些免疫学因素，并强调了采用整体方法理解分枝杆菌与许多宿主细胞相互作用以产生保护性免疫的重要性。
