Department of Biomedical and Molecular Sciences, Queen's University, Kingston, ON K7L 3N6, Canada.
Department of Obstetrics and Gynecology, Department of Immunology, Mayo Clinic, Rochester, MN 55905, USA.
Cells. 2022 Dec 6;11(23):3935. doi: 10.3390/cells11233935.
Pregnancy complications can have long-term negative effects on the health of the affected mothers and their children. In this review, we highlight the underlying inflammatory etiologies of common pregnancy complications and discuss how aberrant inflammation may lead to the acquisition of innate immune memory. The latter can be described as a functional epigenetic reprogramming of innate immune cells following an initial exposure to an inflammatory stimulus, ultimately resulting in an altered response following re-exposure to a similar inflammatory stimulus. We propose that aberrant maternal inflammation associated with complications of pregnancy increases the cross-generational risk of developing noncommunicable diseases (i.e., pregnancy complications, cardiovascular disease, and metabolic disease) through a process mediated by innate immune memory. Elucidating a role for innate immune memory in the cross-generational health consequences of pregnancy complications may lead to the development of novel strategies aimed at reducing the long-term risk of disease.
妊娠并发症会对母婴健康产生长期的负面影响。在这篇综述中，我们强调了常见妊娠并发症的潜在炎症病因，并讨论了异常炎症如何导致固有免疫记忆的获得。后者可以被描述为固有免疫细胞在初次暴露于炎症刺激后发生的功能表观遗传重编程，最终导致在再次暴露于类似炎症刺激时产生改变的反应。我们提出，与妊娠并发症相关的异常母体炎症会通过固有免疫记忆介导的过程增加跨代患上非传染性疾病（即妊娠并发症、心血管疾病和代谢疾病）的风险。阐明固有免疫记忆在妊娠并发症对跨代健康影响中的作用，可能会促使人们开发出旨在降低疾病长期风险的新策略。
