癌症和自身免疫性疾病发病率中的性别偏见与人类组织中的线粒体基因表达呈强正相关。
Sex Biases in Cancer and Autoimmune Disease Incidence Are Strongly Positively Correlated with Mitochondrial Gene Expression across Human Tissues.
作者信息
Crawford David R, Sinha Sanju, Nair Nishanth Ulhas, Ryan Bríd M, Barnholtz-Sloan Jill S, Mount Stephen M, Erez Ayelet, Aldape Kenneth, Castle Philip E, Rajagopal Padma S, Day Chi-Ping, Schäffer Alejandro A, Ruppin Eytan
机构信息
Cancer Data Science Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, MD 20742, USA.
出版信息
Cancers (Basel). 2022 Nov 29;14(23):5885. doi: 10.3390/cancers14235885.
Cancer occurs more frequently in men while autoimmune diseases (AIDs) occur more frequently in women. To explore whether these sex biases have a common basis, we collected 167 AID incidence studies from many countries for tissues that have both a cancer type and an AID that arise from that tissue. Analyzing a total of 182 country-specific, tissue-matched cancer-AID incidence rate sex bias data pairs, we find that, indeed, the sex biases observed in the incidence of AIDs and cancers that occur in the same tissue are positively correlated across human tissues. The common key factor whose levels across human tissues are most strongly associated with these incidence rate sex biases is the sex bias in the expression of the 37 genes encoded in the mitochondrial genome.
癌症在男性中更为常见，而自身免疫性疾病（AIDs）在女性中更为常见。为了探究这些性别差异是否有共同的基础，我们从许多国家收集了167项关于具有癌症类型和源自该组织的自身免疫性疾病的组织的AID发病率研究。分析总共182对特定国家、组织匹配的癌症 - AID发病率性别差异数据对，我们发现，确实，在同一组织中发生的AIDs和癌症发病率中观察到的性别差异在人体组织中呈正相关。在人体组织中水平与这些发病率性别差异最密切相关的共同关键因素是线粒体基因组中编码的37个基因表达中的性别差异。
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