Bumroongkit Chaiwat, Deesomchok Athavudh, Liwsrisakun Chalerm, Pothirat Chaicharn, Theerakittikul Theerakorn, Limsukon Atikun, Trongtrakul Konlawij, Tajarernmuang Pattraporn, Niyatiwatchanchai Nutchanok, Phrommintikul Arintaya, Chaikitmongkol Tul, Euathrongchit Juntima, Rimsukcharoenchai Chartaroon, Inchai Juthamas, Chaiwong Warawut
Division of Pulmonary, Critical Care, and Allergy, Department of Internal Medicine, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand.
Division of Cardiology, Department of Internal Medicine, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand.
J Clin Med. 2022 Nov 25;11(23):6954. doi: 10.3390/jcm11236954.
Acute pulmonary embolism (APE) is a common condition with increasing worldwide incidence. However, the clinical characteristics, risk factors, and clinical outcomes of APE in the Asian population especially in the Thai population are still limited. Therefore, the objective of this study was to identify the clinical characteristics, risk factors, and clinical outcomes of APE in the Asian population.
A cross-sectional study was conducted on patients diagnosed with APE at Chiang Mai University Hospital, Thailand during 2011-2020.
During the study period, 696 patients confirmed the diagnosis of APE with a mean age of 57.7 ± 15.7 years and 41.1% males. APE was suspected in 468 of 696 patients (67.2%), while 228 patients (32.8%) had incidental PE. Active malignancy during treatment was found in 388 (55.7%). Dyspnea, cough, and chest pain were the most common presenting symptoms. Respiratory failure was found in 129 patients (18.6%). The thirty-day all-cause mortality rate was 19.1%. PE-related mortality was 5.6%. Most PE-related mortality was high-risk PE.
APE was not uncommon in the Asian population. Active cancer, especially lung cancer was the most common risk factors. High-risk and intermediate-high-risk PE were associated with high mortality. Risk stratification and prompt management are warranted to improve outcomes.
急性肺栓塞（APE）是一种常见疾病，在全球范围内发病率呈上升趋势。然而，亚洲人群尤其是泰国人群中APE的临床特征、危险因素和临床结局仍然有限。因此，本研究的目的是确定亚洲人群中APE的临床特征、危险因素和临床结局。
对2011年至2020年期间在泰国清迈大学医院诊断为APE的患者进行了一项横断面研究。
在研究期间，696例患者确诊为APE，平均年龄为57.7±15.7岁，男性占41.1%。696例患者中有468例（67.2%）疑似APE，而228例患者（32.8%）为偶然发现的肺栓塞。在治疗期间发现388例（55.7%）有活动性恶性肿瘤。呼吸困难、咳嗽和胸痛是最常见的首发症状。129例患者（18.6%）出现呼吸衰竭。30天全因死亡率为19.1%。肺栓塞相关死亡率为5.6%。大多数肺栓塞相关死亡为高危肺栓塞。
APE在亚洲人群中并不罕见。活动性癌症，尤其是肺癌是最常见的危险因素。高危和中高危肺栓塞与高死亡率相关。有必要进行危险分层并及时处理以改善预后。
