多种含四环素的铋剂四联疗法联合其他抗生素及根除治疗。
Multiple Bismuth Quadruple Therapy Containing Tetracyclines Combined with Other Antibiotics and Eradication Therapy.
作者信息
Sun Yingchao, Zhu Mengjia, Yue Lei, Hu Weiling
机构信息
Department of Gastroenterology, Sir Run Run Shaw Hospital, Medical School, Zhejiang University, Hangzhou 310016, China.
Institute of Gastroenterology, Zhejiang University (IGZJU), Hangzhou 310027, China.
出版信息
J Clin Med. 2022 Nov 28;11(23):7040. doi: 10.3390/jcm11237040.
Abstract
(HP) infection is closely associated with the development of chronic gastritis, peptic ulcer, and gastric cancer. However, the resistance rate of strains to antibiotics such as clarithromycin, metronidazole, and levofloxacin has increased significantly, resulting in a significant decrease in the eradication efficacy of commonly used regimens. Tetracycline has received the attention of domestic and foreign scholars because of its low resistance. The purpose of this review is to provide an update on the tetracycline-containing bismuth quadruple eradication therapy for infection and review the efficacy and safety of the regimens, hoping to provide guidance for clinical practice.
摘要
幽门螺杆菌（HP）感染与慢性胃炎、消化性溃疡及胃癌的发生密切相关。然而，菌株对克拉霉素、甲硝唑和左氧氟沙星等抗生素的耐药率显著上升，导致常用治疗方案的根除疗效大幅下降。四环素因其低耐药性而受到国内外学者的关注。本综述的目的是提供含四环素铋剂四联根除幽门螺杆菌治疗的最新信息，并回顾这些方案的疗效和安全性，希望能为临床实践提供指导。
相似文献
1
Multiple Bismuth Quadruple Therapy Containing Tetracyclines Combined with Other Antibiotics and Eradication Therapy.多种含四环素的铋剂四联疗法联合其他抗生素及根除治疗。
J Clin Med. 2022 Nov 28;11(23):7040. doi: 10.3390/jcm11237040.
2
Amoxicillin or tetracycline in bismuth-containing quadruple therapy as first-line treatment for infection.铋剂四联疗法中阿莫西林或四环素作为一线治疗 感染。
Gut Microbes. 2020 Sep 2;11(5):1314-1323. doi: 10.1080/19490976.2020.1754118. Epub 2020 May 2.
3
Novel and Effective Therapeutic Regimens for in an Era of Increasing Antibiotic Resistance.抗生素耐药性不断增加的时代下针对[具体病症，原文缺失]的新型有效治疗方案
Front Cell Infect Microbiol. 2017 May 5;7:168. doi: 10.3389/fcimb.2017.00168. eCollection 2017.
4
A Randomized Controlled Trial Shows that both 14-Day Hybrid and Bismuth Quadruple Therapies Cure Most Patients with Helicobacter pylori Infection in Populations with Moderate Antibiotic Resistance.一项随机对照试验表明，在抗生素耐药率中等的人群中，14 天的混合疗法和铋四联疗法都能治愈大多数幽门螺杆菌感染患者。
Antimicrob Agents Chemother. 2017 Oct 24;61(11). doi: 10.1128/AAC.00140-17. Print 2017 Nov.
5
Efficacy and Tolerability of Two Quadruple Regimens: Bismuth, Omeprazole, Metronidazole with Amoxicillin or Tetracycline as First-Line Treatment for Eradication of Helicobacter Pylori in Patients with Duodenal Ulcer: A Randomized Clinical Trial.铋剂四联疗法（含阿莫西林或四环素）与奥美拉唑、甲硝唑三联疗法作为一线治疗方案根除十二指肠溃疡患者幽门螺杆菌的疗效和耐受性：一项随机临床试验。
PLoS One. 2018 Jun 11;13(6):e0197096. doi: 10.1371/journal.pone.0197096. eCollection 2018.
6
First-line treatment of Helicobacter pylori in Lebanon: Comparison of bismuth-containing quadruple therapy versus 14-days sequential therapy.黎巴嫩幽门螺杆菌的一线治疗：含铋四联疗法与 14 天序贯疗法的比较。
Microb Pathog. 2018 Apr;117:23-26. doi: 10.1016/j.micpath.2018.02.010. Epub 2018 Feb 8.
7
Efficacy of bismuth-containing quadruple therapies for clarithromycin-, metronidazole-, and fluoroquinolone-resistant Helicobacter pylori infections in a prospective study.前瞻性研究中含铋四联疗法对克拉霉素、甲硝唑和氟喹诺酮耐药幽门螺杆菌感染的疗效。
Clin Gastroenterol Hepatol. 2013 Jul;11(7):802-7.e1. doi: 10.1016/j.cgh.2013.01.008. Epub 2013 Jan 29.
8
The Toronto Consensus for the Treatment of Helicobacter pylori Infection in Adults.《多伦多成人幽门螺杆菌感染治疗共识》。
Gastroenterology. 2016 Jul;151(1):51-69.e14. doi: 10.1053/j.gastro.2016.04.006. Epub 2016 Apr 19.
9
Comparison of sequential therapy and amoxicillin/tetracycline containing bismuth quadruple therapy for the first-line eradication of Helicobacter pylori: a prospective, multi-center, randomized clinical trial.序贯疗法与含阿莫西林/四环素的铋剂四联疗法一线根除幽门螺杆菌的比较：一项前瞻性、多中心、随机临床试验。
BMC Gastroenterol. 2016 Jul 26;16(1):79. doi: 10.1186/s12876-016-0490-8.
10
Helicobacter pylori eradication therapy.幽门螺杆菌根除治疗。
Future Microbiol. 2010 Apr;5(4):639-48. doi: 10.2217/fmb.10.25.
引用本文的文献
1
Clinical Effectiveness of Penicillin-Free Therapies in First-Line and Rescue Treatments for : A Systematic Review.无青霉素疗法在一线和挽救治疗中的临床疗效：一项系统评价
Antibiotics (Basel). 2025 May 8;14(5):476. doi: 10.3390/antibiotics14050476.
2
Newer, Older, and Alternative Agents for the Eradication of Infection: A Narrative Review.用于根除感染的新型、传统及替代药物：一项叙述性综述
Antibiotics (Basel). 2023 May 23;12(6):946. doi: 10.3390/antibiotics12060946.
3
Evolution of Resistance to Antibiotics: A Topic of Increasing Concern.抗生素耐药性的演变：一个日益受到关注的话题。
Antibiotics (Basel). 2023 Feb 4;12(2):332. doi: 10.3390/antibiotics12020332.
本文引用的文献
1
Management of infection: the Maastricht VI/Florence consensus report.感染的管理：马斯特里赫特VI/佛罗伦萨共识报告
Gut. 2022 Aug 8. doi: 10.1136/gutjnl-2022-327745.
2
Management of Helicobacter pylori infection: Guidelines of the Italian Society of Gastroenterology (SIGE) and the Italian Society of Digestive Endoscopy (SIED).幽门螺杆菌感染的管理：意大利胃肠病学会（SIGE）和意大利消化内镜学会（SIED）指南
Dig Liver Dis. 2022 Sep;54(9):1153-1161. doi: 10.1016/j.dld.2022.06.019. Epub 2022 Jul 10.
3
Comparative Effectiveness of Various Eradication Regimens for Helicobacter Pylori Infection in the Northeastern Region of Poland.波兰东北部地区各种幽门螺杆菌感染根除方案的疗效比较。
Int J Environ Res Public Health. 2022 Jun 6;19(11):6921. doi: 10.3390/ijerph19116921.
4
Diagnosis and Treatment of Infection.感染的诊断与治疗
Annu Rev Med. 2022 Jan 27;73:183-195. doi: 10.1146/annurev-med-042220-020814.
5
Single Capsule Bismuth Quadruple Therapy for Eradication of Infection: A Real-Life Study.单粒胶囊铋四联疗法根除感染的真实生活研究
Front Pharmacol. 2021 Apr 29;12:667584. doi: 10.3389/fphar.2021.667584. eCollection 2021.
6
Is a Potassium-Competitive Acid Blocker Truly Superior to Proton Pump Inhibitors in Terms of Eradication?在根除方面，钾离子竞争型酸阻滞剂真的优于质子泵抑制剂吗？
Gut Liver. 2021 Nov 15;15(6):799-810. doi: 10.5009/gnl20242.
7
Screening and eradication of for gastric cancer prevention: the Taipei global consensus.胃癌预防的筛查和根除：台北全球共识。
Gut. 2020 Dec;69(12):2093-2112. doi: 10.1136/gutjnl-2020-322368. Epub 2020 Oct 1.
8
Bismuth quadruple regimen with tetracycline or doxycycline versus three-in-one single capsule as third-line rescue therapy for Helicobacter pylori infection: Spanish data of the European Helicobacter pylori Registry (Hp-EuReg).铋四联疗法联合四环素或多西环素与三联单胶囊作为幽门螺杆菌感染的三线挽救治疗：欧洲幽门螺杆菌注册研究（Hp-EuReg）的西班牙数据。
Helicobacter. 2020 Oct;25(5):e12722. doi: 10.1111/hel.12722. Epub 2020 Jul 13.
9
A randomized, multicenter and noninferiority study of amoxicillin plus berberine vs tetracycline plus furazolidone in quadruple therapy for Helicobacter pylori rescue treatment.阿莫西林加小檗碱与四环素加呋喃唑酮四联疗法补救治疗幽门螺杆菌的随机、多中心、非劣效性研究。
J Dig Dis. 2020 May;21(5):256-263. doi: 10.1111/1751-2980.12870. Epub 2020 Jun 9.
10
Non-bismuth and bismuth quadruple therapies based on previous clarithromycin exposure are as effective and safe in an area of high clarithromycin resistance: A real-life study.既往克拉霉素暴露患者应用非铋剂和铋剂四联疗法的有效性和安全性在高克拉霉素耐药地区相当：一项真实世界研究。
Helicobacter. 2020 Aug;25(4):e12694. doi: 10.1111/hel.12694. Epub 2020 Apr 20.
Zotero 插件