Sun Yingchao, Zhu Mengjia, Yue Lei, Hu Weiling
Department of Gastroenterology, Sir Run Run Shaw Hospital, Medical School, Zhejiang University, Hangzhou 310016, China.
Institute of Gastroenterology, Zhejiang University (IGZJU), Hangzhou 310027, China.
J Clin Med. 2022 Nov 28;11(23):7040. doi: 10.3390/jcm11237040.
(HP) infection is closely associated with the development of chronic gastritis, peptic ulcer, and gastric cancer. However, the resistance rate of strains to antibiotics such as clarithromycin, metronidazole, and levofloxacin has increased significantly, resulting in a significant decrease in the eradication efficacy of commonly used regimens. Tetracycline has received the attention of domestic and foreign scholars because of its low resistance. The purpose of this review is to provide an update on the tetracycline-containing bismuth quadruple eradication therapy for infection and review the efficacy and safety of the regimens, hoping to provide guidance for clinical practice.
幽门螺杆菌（HP）感染与慢性胃炎、消化性溃疡及胃癌的发生密切相关。然而，菌株对克拉霉素、甲硝唑和左氧氟沙星等抗生素的耐药率显著上升，导致常用治疗方案的根除疗效大幅下降。四环素因其低耐药性而受到国内外学者的关注。本综述的目的是提供含四环素铋剂四联根除幽门螺杆菌治疗的最新信息，并回顾这些方案的疗效和安全性，希望能为临床实践提供指导。
