Elmarzouky Zeyad M, Hsiung Ming-Chon, Darwish Amr, Dulal Subash, Maturi Bhanu, Yin Wei-Hsian, Lee Yung-Tsai, Tsao Tien-Ping, Wei Jeng, Nanda Navin C
Division of Cardiology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35305, USA.
Division of Cardiology, Cheng Hsin General Hospital, Taipei 112, Taiwan.
J Clin Med. 2022 Nov 29;11(23):7084. doi: 10.3390/jcm11237084.
The aim of this study is to describe, for the first time to our knowledge, the utilization of both two-dimensional (2D) and three-dimensional (3D) transesophageal echocardiography (TEE) in successfully performing transcatheter mitral valve (MV) in bioprosthetic MV/MV annulopasty ring implantation using the apical approach in 12 patients (pts) with co-existing left atrial appendage (LAA) and/or LA (left atrium) body thrombus, which is considered a contraindication for this procedure.
All pts were severely symptomatic with severe bioprosthetic MV stenosis/regurgitation except one with a previous MV annuloplasty ring and severe native MV stenosis. Thrombus in LAA and/or LA body was noted in all by 2D and 3DTEE. All were at high/prohibitive risk for redo operation and all refused surgery. Utilizing both 2D and 3DTEE, especially 3DTEE, guidewires and the prosthesis deployment system could be manipulated under direct vision into the LA avoiding any contact with the thrombus. The procedure was successful in all with amelioration of symptoms and no embolic or other complications over a mean follow-up of 21 months.
Our study demonstrates the feasibility of successfully performing this procedure in pts with thrombus in LAA and/or LA body without any complications.
据我们所知,本研究首次描述了在12例合并左心耳(LAA)和/或左心房(LA)体部血栓的患者中,使用经心尖途径,在生物瓣二尖瓣(MV)/二尖瓣瓣环成形环植入术中,利用二维(2D)和三维(3D)经食管超声心动图(TEE)成功进行经导管二尖瓣(MV)植入,而这种情况被认为是该手术的禁忌证。
除1例曾行二尖瓣瓣环成形术环且存在严重原发性二尖瓣狭窄的患者外,所有患者均有严重的生物瓣二尖瓣狭窄/反流且症状严重。所有患者经二维和三维TEE均发现LAA和/或LA体部有血栓。所有患者再次手术的风险都很高/极高,且均拒绝手术。利用二维和三维TEE,尤其是三维TEE,可在直视下操作导丝和人工瓣膜输送系统进入左心房,避免与血栓接触。所有患者手术均成功,症状改善,平均随访21个月无栓塞或其他并发症。
我们的研究证明了在LAA和/或LA体部有血栓的患者中成功进行该手术且无任何并发症的可行性。