Fisheries College, Jimei University, Xiamen 361021, China.
Key Laboratory of Healthy Mariculture for the East China Sea, Ministry of Agriculture and Rural, Xiamen 361021, China.
Int J Mol Sci. 2022 Dec 1;23(23):15136. doi: 10.3390/ijms232315136.
SARS-CoV-2 as a zoonotic virus has significantly affected daily life and social behavior since its outbreak in late 2019. The concerns over its transmission through different media directly or indirectly have evoked great attention about the survival of SARS-CoV-2 virions in the environment and its potential infection of other animals. To evaluate the risk of infection by SARS-CoV-2 and to counteract the COVID-19 disease, extensive studies have been performed to understand SARS-CoV-2 biogenesis and its pathogenesis. This review mainly focuses on the molecular architecture of SARS-CoV-2, its potential for infecting marine animals, and the prospect of drug discovery using marine natural products to combat SARS-CoV-2. The main purposes of this review are to piece together progress in SARS-CoV-2 functional genomic studies and antiviral drug development, and to raise our awareness of marine animal safety on exposure to SARS-CoV-2.
自 2019 年底爆发以来，SARS-CoV-2 作为一种人畜共患病毒，极大地影响了人们的日常生活和社会行为。人们对其通过不同媒介直接或间接传播的担忧，引起了对 SARS-CoV-2 病毒在环境中的存活及其潜在感染其他动物的极大关注。为了评估感染 SARS-CoV-2 的风险并对抗 COVID-19 疾病，已经进行了广泛的研究以了解 SARS-CoV-2 的生物发生及其发病机制。本综述主要集中在 SARS-CoV-2 的分子结构、其感染海洋动物的潜力，以及利用海洋天然产物发现药物来对抗 SARS-CoV-2 的前景。本综述的主要目的是整理 SARS-CoV-2 功能基因组研究和抗病毒药物开发的进展，并提高我们对海洋动物接触 SARS-CoV-2 时的安全意识。
