• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

环状 RNA_0078767 通过靶向 microRNA-889 上调 Kruppel 样因子 9 的表达，从而抑制骨肉瘤的进展。

Circular RNA_0078767 upregulates Kruppel-like factor 9 expression by targeting microRNA-889, thereby inhibiting the progression of osteosarcoma.

机构信息

Medical College, Yangzhou University, Yangzhou 225009, Jiangsu, China.

Department of Orthopedics, Lishui Hospital of Chinese Medicine Affiliated to Yangzhou University Medical College, Nanjing211299, Jiangsu, China.

出版信息

Bioengineered. 2022 Jun;13(6):14313-14328. doi: 10.1080/21655979.2022.2084257.

DOI:10.1080/21655979.2022.2084257
PMID:35758280
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9342251/
Abstract

Among kids and juveniles, osteosarcoma (OS) is a common bone malignancy. Circular RNAs (circs, circRNAs) play important roles in multiple malignancies including OS, yet circ_0078767's biological functions in OS are far from well elucidated. This study is targeted at understanding circ_0078767's biological functions in OS and its molecular mechanisms. This study confirmed that circ_0078767 expression was reduced in OS cell lines and tissues. Circ_0078767 overexpression remarkably inhibited OS cell growth, migration, invasion, epithelial-mesenchymal transition (EMT), and promoted apoptosis, whereas circ_0078767 knockdown resulted in the opposite effects. MicroRNA-889 (miR-889) was targeted and regulated by circ_0078767, and miR-889 could negatively modulate Kruppel-like factor 9 (KLF9) expression. Besides, circ_0078767 positively regulated KLF9 expression in OS cells via repressing miR-889. In conclusion, circ_0078767 enhances KLF9 expression by targeting miR-889 to inhibit OS progression.

摘要

在儿童和青少年中，骨肉瘤（OS）是一种常见的骨恶性肿瘤。环状 RNA（circs，circRNAs）在包括 OS 在内的多种恶性肿瘤中发挥重要作用，但 circ_0078767 在 OS 中的生物学功能仍远未阐明。本研究旨在探讨 circ_0078767 在 OS 中的生物学功能及其分子机制。本研究证实 circ_0078767 在 OS 细胞系和组织中的表达降低。circ_0078767 过表达显著抑制 OS 细胞的生长、迁移、侵袭、上皮-间充质转化（EMT），并促进细胞凋亡，而 circ_0078767 敲低则产生相反的效果。circ_0078767 靶向并调节 microRNA-889（miR-889），而 miR-889 可以负调控 Kruppel 样因子 9（KLF9）的表达。此外，circ_0078767 通过抑制 miR-889 正向调节 OS 细胞中的 KLF9 表达。总之，circ_0078767 通过靶向 miR-889 增强 KLF9 表达，从而抑制 OS 进展。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b1c9/9342251/be2b9b315f3d/KBIE_A_2084257_F0006_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b1c9/9342251/7889debff6cf/KBIE_A_2084257_UF0001_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b1c9/9342251/2a56db7acc6b/KBIE_A_2084257_F0001_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b1c9/9342251/0663b32b3fe6/KBIE_A_2084257_F0002_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b1c9/9342251/b8aa67120d5e/KBIE_A_2084257_F0003_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b1c9/9342251/09c6eba3088b/KBIE_A_2084257_F0004_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b1c9/9342251/8478e3913102/KBIE_A_2084257_F0005_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b1c9/9342251/be2b9b315f3d/KBIE_A_2084257_F0006_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b1c9/9342251/7889debff6cf/KBIE_A_2084257_UF0001_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b1c9/9342251/2a56db7acc6b/KBIE_A_2084257_F0001_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b1c9/9342251/0663b32b3fe6/KBIE_A_2084257_F0002_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b1c9/9342251/b8aa67120d5e/KBIE_A_2084257_F0003_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b1c9/9342251/09c6eba3088b/KBIE_A_2084257_F0004_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b1c9/9342251/8478e3913102/KBIE_A_2084257_F0005_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b1c9/9342251/be2b9b315f3d/KBIE_A_2084257_F0006_OC.jpg

相似文献

1
Circular RNA_0078767 upregulates Kruppel-like factor 9 expression by targeting microRNA-889, thereby inhibiting the progression of osteosarcoma.环状 RNA_0078767 通过靶向 microRNA-889 上调 Kruppel 样因子 9 的表达，从而抑制骨肉瘤的进展。
Bioengineered. 2022 Jun;13(6):14313-14328. doi: 10.1080/21655979.2022.2084257.
2
Circ_0001174 facilitates osteosarcoma cell proliferation, migration, and invasion by targeting the miR-186-5p/MACC1 axis.环状 RNA 0001174 通过靶向 miR-186-5p/MACC1 轴促进骨肉瘤细胞的增殖、迁移和侵袭。
J Orthop Surg Res. 2022 Mar 12;17(1):159. doi: 10.1186/s13018-022-03059-8.
3
Circular RNA circ_UBAP2 facilitates the progression of osteosarcoma by regulating microRNA miR-637/high-mobility group box (HMGB) 2 axis.环状 RNA circ_UBAP2 通过调控 microRNA miR-637/高迁移率族蛋白（HMGB）2 轴促进骨肉瘤的进展。
Bioengineered. 2022 Feb;13(2):4411-4427. doi: 10.1080/21655979.2022.2033447.
4
Circular RNA 0102049 suppresses the progression of osteosarcoma through modulating miR-520g-3p/PLK2 axis.环状 RNA 0102049 通过调控 miR-520g-3p/PLK2 轴抑制骨肉瘤的进展。
Bioengineered. 2021 Dec;12(1):2022-2032. doi: 10.1080/21655979.2021.1923259.
5
Hsa_circ_0008934 promotes the proliferation and migration of osteosarcoma cells by targeting miR-145-5p to enhance E2F3 expression.Hsa_circ_0008934通过靶向miR-145-5p增强E2F3表达来促进骨肉瘤细胞的增殖和迁移。
Int J Biochem Cell Biol. 2020 Oct;127:105826. doi: 10.1016/j.biocel.2020.105826. Epub 2020 Aug 18.
6
Hsa_circ_0001017 promotes cell proliferation, migration and invasion in osteosarcoma by sponging miR-145-5p.Hsa_circ_0001017 通过海绵吸附 miR-145-5p 促进骨肉瘤细胞增殖、迁移和侵袭。
J Orthop Surg Res. 2022 Mar 28;17(1):184. doi: 10.1186/s13018-022-03062-z.
7
Tanshinone I restrains osteosarcoma progression by regulating circ_0000376/miR-432-5p/BCL2 axis.丹参酮 I 通过调控 circ_0000376/miR-432-5p/BCL2 轴抑制骨肉瘤进展。
Mol Cell Biochem. 2022 Jan;477(1):1-13. doi: 10.1007/s11010-021-04257-4. Epub 2021 Sep 16.
8
Hsa_circ_0003732 promotes osteosarcoma cells proliferation via miR-545/CCNA2 axis.hsa_circ_0003732 通过 miR-545/CCNA2 轴促进骨肉瘤细胞增殖。
Biosci Rep. 2020 Jun 26;40(6). doi: 10.1042/BSR20191552.
9
Hsa_circ_0001480 affects osteosarcoma progression by regulating the miR-363-3p/IBSP pathway.hsa_circ_0001480 通过调控 miR-363-3p/IBSP 通路影响骨肉瘤的进展。
Biotechnol Appl Biochem. 2024 Aug;71(4):721-732. doi: 10.1002/bab.2571. Epub 2024 Feb 26.
10
Exosome-transmitted circular RNA circ-LMO7 facilitates the progression of osteosarcoma by regulating miR-21-5p/ARHGAP24 axis.外泌体传递的环状 RNA circ-LMO7 通过调节 miR-21-5p/ARHGAP24 轴促进骨肉瘤的进展。
Cancer Biol Ther. 2024 Dec 31;25(1):2343450. doi: 10.1080/15384047.2024.2343450. Epub 2024 May 14.

引用本文的文献

1
Epithelial-Mesenchymal Transition in Osteosarcoma as a Key Driver of Pulmonary Metastasis.骨肉瘤中的上皮-间质转化作为肺转移的关键驱动因素
Cancers (Basel). 2025 Sep 6;17(17):2922. doi: 10.3390/cancers17172922.
2
Krüppel-like factors family in health and disease.健康与疾病中的Krüppel样因子家族。
MedComm (2020). 2024 Sep 10;5(9):e723. doi: 10.1002/mco2.723. eCollection 2024 Sep.
3
KLF transcription factors in bone diseases.KLF 转录因子在骨骼疾病中的作用。

本文引用的文献

1
KLF9 regulates miR-338-3p/NRCAM axis to block the progression of osteosarcoma cells.KLF9通过调控miR-338-3p/NRCAM轴来阻断骨肉瘤细胞的进展。
J Cancer. 2022 Mar 28;13(6):2029-2039. doi: 10.7150/jca.63533. eCollection 2022.
2
Tumour-suppressing functions of the lncRNA MBNL1-AS1/miR-889-3p/KLF9 axis in human breast cancer cells.MBNL1-AS1/miR-889-3p/KLF9 轴在人乳腺癌细胞中的抑瘤功能。
Cell Cycle. 2022 May;21(9):908-920. doi: 10.1080/15384101.2022.2034254. Epub 2022 Feb 3.
3
Circular RNA circ_0000644 promotes papillary thyroid cancer progression via sponging miR-1205 and regulating E2F3 expression.
J Cell Mol Med. 2024 Apr;28(8):e18278. doi: 10.1111/jcmm.18278.
4
Krüppel-like Factor-9 and Krüppel-like Factor-13: Highly Related, Multi-Functional, Transcriptional Repressors and Activators of Oncogenesis.Krüppel样因子9和Krüppel样因子13：高度相关、多功能的肿瘤发生转录抑制因子和激活因子。
Cancers (Basel). 2023 Nov 30;15(23):5667. doi: 10.3390/cancers15235667.
5
Proteomic analysis to identification of hypoxia related markers in spinal tuberculosis: a study based on weighted gene co-expression network analysis and machine learning.基于加权基因共表达网络分析和机器学习的脊柱结核缺氧相关标志物的蛋白质组学分析：一项研究
BMC Med Genomics. 2023 Jun 20;16(1):142. doi: 10.1186/s12920-023-01566-z.
6
Kruppel-like Factors in Skeletal Physiology and Pathologies.Kruppel 样因子在骨骼生理学和病理学中的作用
Int J Mol Sci. 2022 Dec 2;23(23):15174. doi: 10.3390/ijms232315174.
环状 RNA circ_0000644 通过海绵吸附 miR-1205 和调控 E2F3 表达促进甲状腺乳头状癌进展。
Cell Cycle. 2022 Jan;21(2):126-139. doi: 10.1080/15384101.2021.2012334. Epub 2021 Dec 17.
4
Hsa_circ_0030586 promotes epithelial-mesenchymal transition in prostate cancer via PI3K-AKT signaling.hsa_circ_0030586 通过 PI3K-AKT 信号通路促进前列腺癌细胞上皮-间充质转化。
Bioengineered. 2021 Dec;12(2):11089-11107. doi: 10.1080/21655979.2021.2008217.
5
Hsa_circ_0088212-mediated miR-520 h/APOA1 axis inhibits osteosarcoma progression.人源环状RNA hsa_circ_0088212介导的miR-520h/载脂蛋白A1轴抑制骨肉瘤进展。
Transl Oncol. 2021 Dec;14(12):101219. doi: 10.1016/j.tranon.2021.101219. Epub 2021 Sep 21.
6
Enhanced expression of miR-889 forecasts an unfavorable prognosis and facilitates cell progression in hepatocellular carcinoma.miR-889的表达增强预示着肝细胞癌预后不良并促进细胞进展。
Diagn Pathol. 2021 Jun 11;16(1):51. doi: 10.1186/s13000-021-01111-5.
7
Hsa_circ_0010220 regulates miR-198/Syntaxin 6 axis to promote osteosarcoma progression.人源环状RNA hsa_circ_0010220通过调控miR-198/ Syntaxin 6轴促进骨肉瘤进展。
J Bone Oncol. 2021 Apr 22;28:100360. doi: 10.1016/j.jbo.2021.100360. eCollection 2021 Jun.
8
Oleanolic acid inhibits osteosarcoma cell proliferation and invasion by suppressing the SOX9/Wnt1 signaling pathway.齐墩果酸通过抑制SOX9/Wnt1信号通路抑制骨肉瘤细胞的增殖和侵袭。
Exp Ther Med. 2021 May;21(5):443. doi: 10.3892/etm.2021.9883. Epub 2021 Feb 28.
9
Circular RNA circ_0000467 regulates colorectal cancer development via miR-382-5p/EN2 axis.环状 RNA circ_0000467 通过 miR-382-5p/EN2 轴调控结直肠癌的发生发展。
Bioengineered. 2021 Dec;12(1):886-897. doi: 10.1080/21655979.2021.1889130.
10
LncRNA GATA6-AS1 Inhibits the Progression of Non-Small Cell Lung Cancer via Repressing microRNA-543 to Up-Regulating RKIP.长链非编码RNA GATA6-AS1通过抑制微小RNA-543上调RKIP来抑制非小细胞肺癌的进展。
Cancer Manag Res. 2020 Sep 29;12:9327-9338. doi: 10.2147/CMAR.S254184. eCollection 2020.