Salmon-Cabrales Itzel S, de la Garza-Kalife David A, García-González Gabriel, Estrada-Rodríguez Ana E, Jiménez-Gutiérrez Marco Antonio, Santoyo-Suárez Michelle G, Rodríguez-Núñez Oscar, Garza-Treviño Elsa N, Benítez-Chao Diego F, Padilla-Rivas Gerardo R, Islas Jose Francisco
Laboratorio de Terapia Celular, Departamento de Bioquímica y Medicina Molecular, Facultad de Medicina, Universidad Autónoma de Nuevo León, Av. Dr. José Eleuterio González 235, Monterrey 64460, Nuevo León, Mexico.
Departmento de Ciencias Básicas, Vicerrectoría de Ciencias de la Salud, Universidad de Monterrey, Ignacio Morones Prieto 4500, Jesus M. Garza, San Pedro Garza García 66238, Nuevo León, Mexico.
Life (Basel). 2024 Dec 17;14(12):1671. doi: 10.3390/life14121671.
The kidneys contribute to the overall health of an organism by maintaining systemic homeostasis. This process involves various biological mechanisms, in which the Krüppel-like factors (KLFs), a family of transcription factors, are essential for regulating development, differentiation, proliferation, and cellular apoptosis. They also play a role in the metabolic regulation of essential nutrients, such as glucose and lipids. The dysregulation of these transcription factors is associated with the development of various pathologies, which can ultimately lead to renal fibrosis, severely compromising kidney function. In this context, the present article provides a comprehensive review of the existing literature, offering an enriching analysis of the findings related to the role of KLFs in nephrology, while also highlighting their potential therapeutic role in the treatment of renal diseases.
肾脏通过维持全身内环境稳定来促进生物体的整体健康。这个过程涉及多种生物学机制，其中，作为一类转录因子的Krüppel样因子（KLFs）对于调节发育、分化、增殖和细胞凋亡至关重要。它们在葡萄糖和脂质等必需营养素的代谢调节中也发挥作用。这些转录因子的失调与各种病理状况的发生发展相关，最终可导致肾纤维化，严重损害肾功能。在此背景下，本文对现有文献进行了全面综述，对与KLFs在肾脏病学中的作用相关的研究结果进行了丰富分析，同时也强调了它们在肾脏疾病治疗中的潜在治疗作用。
