表观遗传学在神经炎症驱动性疾病中的作用。

The Role of Epigenetics in Neuroinflammatory-Driven Diseases.

机构信息

Department of Biomedical and Biotechnological Sciences, Section of Biochemistry, University of Catania, 95123 Catania, Italy.

Department of Biomedical and Biotechnological Sciences, Section of Physiology, University of Catania, 95123 Catania, Italy.

出版信息

Int J Mol Sci. 2022 Dec 2;23(23):15218. doi: 10.3390/ijms232315218.

DOI:10.3390/ijms232315218

PMID:36499544

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9740629/

Abstract

Neurodegenerative disorders are characterized by the progressive loss of central and/or peripheral nervous system neurons. Within this context, neuroinflammation comes up as one of the main factors linked to neurodegeneration progression. In fact, neuroinflammation has been recognized as an outstanding factor for Alzheimer's disease (AD), amyotrophic lateral sclerosis (ALS), Parkinson's disease (PD), and multiple sclerosis (MS). Interestingly, neuroinflammatory diseases are characterized by dramatic changes in the epigenetic profile, which might provide novel prognostic and therapeutic factors towards neuroinflammatory treatment. Deep changes in DNA and histone methylation, along with histone acetylation and altered non-coding RNA expression, have been reported at the onset of inflammatory diseases. The aim of this work is to review the current knowledge on this field.

摘要

神经退行性疾病的特征是中枢和/或周围神经系统神经元的进行性丧失。在这种情况下，神经炎症是与神经退行性进展相关的主要因素之一。事实上，神经炎症已被认为是阿尔茨海默病 (AD)、肌萎缩侧索硬化症 (ALS)、帕金森病 (PD) 和多发性硬化症 (MS) 的一个重要因素。有趣的是，神经炎症性疾病的表观遗传特征发生显著变化，这可能为神经炎症治疗提供新的预后和治疗因素。在炎症性疾病的发病过程中，已经报道了 DNA 和组蛋白甲基化、组蛋白乙酰化以及非编码 RNA 表达改变的深刻变化。本研究旨在综述该领域的最新知识。