Ostrow D G, Goldsmith J, Kalish S B, Chmiel J S, Hadler S C, Phair J P
Sex Transm Dis. 1987 Apr-Jun;14(2):92-7. doi: 10.1097/00007435-198704000-00007.
Of 479 homosexual men immunized with three 20-microgram doses of the hepatitis B vaccine, approximately 15% failed to develop protective titers of antibody to the surface antigen of hepatitis B virus (greater than 10 sample ratio units [SRU]). We revaccinated 34 nonresponders with an additional three doses of vaccine and compared their immunologic status with that of 14 control men who had responded to initial vaccination. Most men (15 of 19) who had measurable antibody to hepatitis B surface antigen (SRU, 2.1-9.9) after initial vaccination responded to revaccination, whereas ten of the remaining 15 nonresponders (SRU, less than 2.1) did not. No single immunologic measure distinguished ultimate responders from nonresponders; however, the initial responders differed from delayed responders and nonresponders by having higher numbers of total lymphocytes, B, T, and T helper and suppressor cells.
在479名接受三次20微克剂量乙肝疫苗免疫的同性恋男性中，约15%未能产生针对乙肝病毒表面抗原的保护性抗体滴度（大于10样本比率单位[SRU]）。我们用另外三针疫苗对34名无反应者进行了再免疫，并将他们的免疫状态与14名对初次疫苗接种有反应的对照男性的免疫状态进行了比较。大多数在初次接种疫苗后对乙肝表面抗原有可测量抗体（SRU，2.1 - 9.9）的男性（19名中的15名）对再免疫有反应，而其余15名无反应者（SRU，小于2.1）中的10名没有反应。没有单一的免疫指标能区分最终的反应者和无反应者；然而，初次反应者与延迟反应者和无反应者的区别在于其总淋巴细胞、B细胞、T细胞以及T辅助细胞和抑制细胞数量较多。
