Department of Organic Chemistry, Faculty of Chemistry, University of Lodz, Tamka 12, 91-403 Lodz, Poland.
Department of Bioanalytics, Medical University of Lublin, Jaczewskiego 8b, 20-090 Lublin, Poland.
Molecules. 2022 Nov 29;27(23):8319. doi: 10.3390/molecules27238319.
New hydroxy- and anilinoindanone derivatives and were synthesized starting from 3-hydroxybenzo[]isoindolinone via the addition of alkyllithium (-BuLi, -BuLi, MeLi or -PrLi) to the carbonyl group, followed by lactam ring opening and, finally, an intramolecular cyclization leading to target compounds. The same starting material was used for the preparation of the new benzo[]phthalazinone derivatives through multi-step reactions. The target derivative was obtained from the corresponding bromolactam by the Buchwald-Hartwig amination. Structures of the obtained compounds were confirmed by the NMR spectra.
新型羟基-和苯胺基茚满酮衍生物 和 是从 3-羟基苯并[]异吲哚啉酮出发，通过烷基锂（-BuLi、-BuLi、MeLi 或 -PrLi）加成到羰基上，然后进行内酰胺开环，最后进行分子内环化得到目标化合物而合成的。同样的起始材料也用于通过多步反应制备新的苯并[]酞嗪酮衍生物 。目标衍生物 是由相应的溴代内酰胺 通过 Buchwald-Hartwig 胺化反应得到的。通过 NMR 谱确认了所得化合物的结构。
