Bassin Jatinder P, Anagani Bhavani, Benham Christopher, Goyal Madhu, Hashemian Maryam, Gerhard Ute
School of Life and Medical Sciences, University of Hertfordshire, Hatfield AL10 9AB, UK.
Molecules. 2016 Jul 23;21(8):967. doi: 10.3390/molecules21080967.
A simple synthetic route affording 27%-85% yields of benzo[6,7][1,5]diazocino[2,1-a]isoindol-12(14H)-one ring systems from readily available 3-(2-oxo-2-phenylethyl) isobenzofuran-1(3H)-ones and 2-(aminomethyl)aniline starting materials in toluene and catalysed by p-toluene-sulfonic acid is developed. The ¹H- and (13)C-NMR spectra of the final products were assigned using a variety of one and two-dimensional NMR experiments. The distinction between the two potential isomers of the final products was made on the basis of heteronuclear multiple bond connectivity (HMBC) NMR spectra.
开发了一种简单的合成路线，以甲苯为溶剂，对甲苯磺酸为催化剂，由易得的3-(2-氧代-2-苯乙基)异苯并呋喃-1(3H)-酮和2-(氨基甲基)苯胺为起始原料，可得到产率为27%-85%的苯并[6,7][1,5]二氮杂环辛并[2,1-a]异吲哚-12(14H)-酮环系。使用多种一维和二维核磁共振实验对最终产物的¹H-和(13)C-NMR光谱进行了归属。基于异核多键连接(HMBC)NMR光谱对最终产物的两种潜在异构体进行了区分。
