基于聚糖的电化学生物传感器：用于检测传染病和癌症生物标志物的有前途的工具。
Glycan-Based Electrochemical Biosensors: Promising Tools for the Detection of Infectious Diseases and Cancer Biomarkers.
机构信息
Max Planck Tandem Group in Nanobioengineering, Institute of Chemistry, Faculty of Natural and Exact Sciences, University of Antioquia, Complejo Ruta N, Calle 67 N°52-20, Medellin 050010, Colombia.
出版信息
Molecules. 2022 Dec 3;27(23):8533. doi: 10.3390/molecules27238533.
Glycan-based electrochemical biosensors are emerging as analytical tools for determining multiple molecular targets relevant to diagnosing infectious diseases and detecting cancer biomarkers. These biosensors allow for the detection of target analytes at ultra-low concentrations, which is mandatory for early disease diagnosis. Nanostructure-decorated platforms have been demonstrated to enhance the analytical performance of electrochemical biosensors. In addition, glycans anchored to electrode platforms as bioreceptors exhibit high specificity toward biomarker detection. Both attributes offer a synergy that allows ultrasensitive detection of molecular targets of clinical interest. In this context, we review recent advances in electrochemical glycobiosensors for detecting infectious diseases and cancer biomarkers focused on colorectal cancer. We also describe general aspects of structural glycobiology, definitions, and classification of electrochemical biosensors and discuss relevant works on electrochemical glycobiosensors in the last ten years. Finally, we summarize the advances in electrochemical glycobiosensors and comment on some challenges and limitations needed to advance toward real clinical applications of these devices.
基于糖的电化学生物传感器作为分析工具，正在涌现出来，用于确定与诊断传染病和检测癌症生物标志物相关的多种分子靶标。这些生物传感器允许以超低浓度检测目标分析物，这对于早期疾病诊断是强制性的。已经证明，纳米结构修饰的平台可以增强电化学生物传感器的分析性能。此外，作为生物受体锚定在电极平台上的糖展示出针对生物标志物检测的高特异性。这两个属性提供了协同作用，允许对临床相关分子靶标的超灵敏检测。在这种情况下，我们综述了电化学糖生物传感器在检测传染病和癌症生物标志物方面的最新进展，重点是结直肠癌。我们还描述了结构糖生物学的一般方面、电化学生物传感器的定义和分类，并讨论了过去十年中电化学糖生物传感器的相关工作。最后，我们总结了电化学生物传感器的进展，并对这些设备推向实际临床应用所需的一些挑战和限制进行了评论。
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