电化学生物传感器用于结直肠癌生物标志物的测量。
Electrochemical biosensors for measurement of colorectal cancer biomarkers.
机构信息
Advanced Micro and Nano-instruments Center, School of Mechanical & Automotive Engineering, Qilu University of Technology (Shandong Academy of Sciences), Jinan, 250353, Shandong, China.
Shandong Analysis and Test Center, Qilu University of Technology (Shandong Academy of Sciences), Jinan, 250014, Shandong, China.
出版信息
Anal Bioanal Chem. 2021 Apr;413(9):2407-2428. doi: 10.1007/s00216-021-03197-8. Epub 2021 Mar 5.
Colorectal cancer (CRC) is associated with one of the highest rates of mortality among cancers worldwide. The early detection and management of CRC is imperative. Biomarkers play an important role in CRC screening tests, CRC treatment, and prognosis and clinical management; thus rapid and sensitive detection of biomarkers is helpful for early detection of CRC. In recent years, electrochemical biosensors for detecting CRC biomarkers have been widely investigated. In this review, different electrochemical detection methods for CRC biomarkers including immunosensors, aptasensors, and genosensors are summarized. Further, representative examples are provided that demonstrate the advantages of electrochemical sensors modified by various nanomaterials. Finally, the limitations and prospects of biomarkers and electrochemical sensors in detection are also discussed. Graphical abstract.
结直肠癌（CRC）是全球死亡率最高的癌症之一。结直肠癌的早期发现和管理至关重要。生物标志物在 CRC 筛查试验、CRC 治疗以及预后和临床管理中发挥着重要作用；因此，快速、灵敏地检测生物标志物有助于早期发现 CRC。近年来，电化学生物传感器在 CRC 生物标志物检测方面得到了广泛的研究。本综述总结了不同的电化学检测方法，包括免疫传感器、适体传感器和基因传感器，用于检测 CRC 生物标志物。进一步提供了具有代表性的例子，说明了各种纳米材料修饰的电化学传感器的优势。最后，还讨论了生物标志物和电化学传感器在检测中的局限性和前景。
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