Nicholas School of the Environment, Duke University, Durham, NC, USA.
Department of Chemical & Biomolecular Engineering, North Carolina State University, Raleigh, NC, USA.
Biofouling. 2022 Oct;38(9):876-888. doi: 10.1080/08927014.2022.2145471. Epub 2022 Dec 12.
The biological impact of chemical formulations used in various coating applications is essential in guiding the development of new materials that directly contact living organisms. To illustrate this point, an investigation addressing the impact of chemical compositions of polydimethylsiloxane networks on a common platform for foul-release biofouling management coatings was conducted. The acute toxicity of network components to barnacle larvae, the impacts of aqueous extracts of crosslinker, silicones and organometallic catalyst on trypsin enzymatic activity, and the impact of assembled networks on barnacle adhesion was evaluated. The outcomes of the study indicate that all components used in the formulation of the silicone network alter trypsin enzymatic activity and have a range of acute toxicity to barnacle larvae. Also, the adhesion strength of barnacles attached to PDMS networks correlates to the network formulation protocol. This information can be used to assess action mechanisms and risk-benefit analysis of PDMS networks.
在各种涂层应用中使用的化学配方的生物影响对于指导直接与生物体接触的新材料的开发至关重要。为了说明这一点，对聚二甲基硅氧烷网络的化学组成对常见的防污生物污垢管理涂层的影响进行了研究。评估了网络成分对藤壶幼虫的急性毒性、交联剂、硅酮和有机金属催化剂的水提取物对胰蛋白酶酶活性的影响，以及组装后的网络对藤壶附着的影响。研究结果表明，硅酮网络配方中使用的所有成分都会改变胰蛋白酶酶活性，并对藤壶幼虫具有不同程度的急性毒性。此外，附着在 PDMS 网络上的藤壶的附着强度与网络配方方案相关。这些信息可用于评估 PDMS 网络的作用机制和风险效益分析。
