Consiglio per la ricerca in agricoltura e l'analisi dell'economia agraria (CREA) - Centro di ricerca Zootecnia e Acquacoltura, 00015 Monterotondo, Rome, Italy.
Associazione Nazionale Allevatori Bovini di razza Pezzata Rossa Italiana, 33100 Udine, Italy.
J Dairy Res. 2022 Nov;89(4):375-381. doi: 10.1017/S0022029922000772. Epub 2022 Dec 12.
CXCL8 (also known as IL-8) is a member of the CXC subfamily of chemokines that binds two of the seven transmembrane G-protein-coupled receptors (GPCRs), CXCR1 and CXCR2, to mediate and regulate leucocyte accumulation and activation at sites of inflammation. They are known to play a critical role in both disease susceptibility and infection outcome. The aim of this study was to investigate the entire sequences of and genes in thirty-one Simmental sires to evaluate the effects of genomic variants on the indexes of the bulls for milk, fat and protein yields, and for somatic cell score (SCS). Five new single nucleotide polymorphisms (SNPs) were found in gene. The analysis of association indicated that one SNP in and two in influenced the considered traits. To evaluate the existence of functional haplotypic effects, combinations among the three genomic variants (SNP 1 in , SNP 6 and SNP 7 in ) were investigated. Four different haplotypic alleles were identified in the experimental population, one of which at a high frequency (61%). Bulls with Hap 4 (G-C-G at SNP 1, SNP 6, and SNP 7 respectively) had more favourable indexes for SCS ( < 0.05). These results suggest that the SNPs in and may be potential genetic markers to improve udder health in the Simmental breed.
CXCL8（也称为 IL-8）是趋化因子 CXC 亚家族的成员，它与两种七跨膜 G 蛋白偶联受体（GPCR），CXCR1 和 CXCR2 结合，以介导和调节白细胞在炎症部位的积累和激活。它们被认为在疾病易感性和感染结果中起着关键作用。本研究的目的是研究 31 头西门塔尔公牛的 和 基因的全长序列，以评估基因组变异对公牛产奶、产脂和产蛋白量以及体细胞评分（SCS）指标的影响。在 基因中发现了五个新的单核苷酸多态性（SNP）。关联分析表明， 基因中的一个 SNP 和 基因中的两个 SNP 影响了所考虑的性状。为了评估功能单倍型效应的存在，研究了三个基因组变异（SNP1 在 ，SNP6 和 SNP7 在 ）之间的组合。在实验群体中鉴定出了四个不同的单倍型等位基因，其中一个高频等位基因（61%）。具有 Hap4（SNP1、SNP6 和 SNP7 分别为 G-C-G）的公牛的 SCS 指数更有利（<0.05）。这些结果表明， 和 中的 SNP 可能是西门塔尔牛品种改善乳房健康的潜在遗传标记。
