Department of Cardiology, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Jayanagar, Wt Road, Medical College Junction, Trivandrum 695011, India.
Abbott Electrophysiology and Heart Failure Department, No 147 3rd Floor, Greams Lane, Greames Road, Chennai 600006, India.
Europace. 2023 Mar 30;25(3):1110-1115. doi: 10.1093/europace/euac239.
The ideal pacing strategy has been the Achilles' heel for patients with congenitally corrected transposition of great arteries (ccTGA) with bradycardia. Various pacing modalities were documented in the literature. This article describes a novel pacing strategy and its feasibility in ccTGA with an intact ventricular septum.
We prospectively recruited three patients with ccTGA who presented with symptomatic complete heart block to our institute and were evaluated. All patients were planned for conduction system pacing. Those who had more than moderate or severe systemic atrioventricular regurgitation and systemic ventricular dysfunction were planned for conduction system pacing with an additional lead in the coronary sinus (CS) tributary, i.e. bundle branch pacing optimized cardiac resynchronization therapy with the intention to achieve incremental benefit. Since right bundle pacing is not described previously and in view of anatomical complexity in location, three-dimensional (3D) anatomical mapping was done with the EnSite system and later right bundle capture is identified conventionally as that of a left bundle in a normal heart. All three patients have stable lead positions and adequate thresholds at short-term follow-up.
In this report, we demonstrated the feasibility of permanent physiological pacing of the systemic ventricle by capturing the right bundle with 3D anatomical mapping guidance, which results in physiological activation of the systemic ventricle.
对于患有先天性矫正型大动脉转位(ccTGA)伴心动过缓的患者,理想的起搏策略一直是一个难题。文献中已经有各种起搏方式的记录。本文描述了一种新的起搏策略及其在室间隔完整的 ccTGA 中的可行性。
我们前瞻性招募了 3 名因完全性心脏传导阻滞而出现症状的 ccTGA 患者到我院进行评估。所有患者均计划进行心脏传导系统起搏。对于那些存在中度或重度以上的系统性房室瓣反流和系统性心室功能障碍的患者,计划进行心脏传导系统起搏,并在冠状窦(CS)分支中额外放置一根导线,即优化心脏再同步治疗的束支起搏,以期获得额外的益处。由于右束支起搏以前没有描述过,而且鉴于其在位置上的解剖复杂性,我们使用 EnSite 系统进行了三维(3D)解剖映射,然后按照正常心脏中左束支的方式常规识别右束支的捕获。所有 3 名患者在短期随访中均具有稳定的导线位置和足够的阈值。
在本报告中,我们通过 3D 解剖映射引导捕获右束支,展示了通过 3D 解剖映射引导捕获右束支实现对系统性心室进行生理性起搏的可行性,从而实现系统性心室的生理性激活。