Bodle Kylie B, Pernat Madeline R, Kirkland Catherine M
Department of Civil Engineering, Montana State, University, 205 Cobleigh Hall, Bozeman, MT, USA.
Center for Biofilm Engineering, Montana State University, 366 Barnard Hall, Bozeman, MT, USA.
Water Air Soil Pollut. 2022 Dec;233(12). doi: 10.1007/s11270-022-05974-2. Epub 2022 Nov 29.
Environmental contamination from pharmaceuticals has received increased attention from researchers in the past 20 years. As such, numerous lab-scale studies have sought to characterize the effects of these contaminants on various targets, as well as determine improved removal methods. Many studies have used lab-scale bioreactors to investigate pharmaceutical effects on wastewater bacteria, as wastewater treatment plants often act as reservoirs for pharmaceuticals. However, few-if any-of these studies report the specific lab materials used during testing, such as tubing or pipette tip type. In this study, the pharmaceuticals erythromycin, diclofenac, and gemfibrozil were exposed to different micropipette tips, syringe filters, and tubing types, and losses over time were evaluated. Losses to tubing and syringe filters were particularly significant and neared 100%, depending on the pharmaceutical compound and length of exposure time. Results discussed herein indicate that pharmaceutical sorption to various lab supplies results in decreases to both dosed and quantified pharmaceutical concentrations. Studies that fail to consider this source of loss may therefore draw inaccurate conclusions about pharmaceutical effects or removal efficiencies.
在过去20年里，药物对环境的污染越来越受到研究人员的关注。因此，许多实验室规模的研究试图描述这些污染物对各种目标的影响，并确定改进的去除方法。许多研究使用实验室规模的生物反应器来研究药物对废水细菌的影响，因为污水处理厂常常充当药物的储存库。然而，这些研究中几乎没有（如果有的话）报告测试过程中使用的具体实验室材料，如管材或移液器吸头类型。在本研究中，将药物红霉素、双氯芬酸和吉非罗齐暴露于不同的移液器吸头、注射器过滤器和管材类型中，并评估随时间的损失情况。管材和注射器过滤器的损失尤为显著，根据药物化合物和暴露时间的长短，损失接近100%。本文讨论的结果表明，药物吸附到各种实验室用品上会导致给药和定量药物浓度的降低。因此，未能考虑这种损失来源的研究可能会对药物效果或去除效率得出不准确的结论。
