Sang Tian, Wang Ying, Wu Ye, Guan Qiao, Yang ZhiXian
Pediatric Department, Peking University First Hospital, Beijing, China.
Front Neurol. 2022 Nov 23;13:957465. doi: 10.3389/fneur.2022.957465. eCollection 2022.
To investigate neonatal electroencephalography (EEG) background activity and electrographic seizures in patients in the pediatric intensive care unit (PICU) who underwent bedside video-electroencephalography (vEEG) monitoring.
A total of 232 pediatric patients admitted or transferred to PICU that underwent vEEG monitoring were retrospectively enrolled in this study, and electrographic status epilepticus was observed after vEEG monitoring.
The median age was 1.56 years [95% confidence interval (CI) = 1.12-2.44]. Electrographic seizures occurred in 88 patients (37.9%), out of which 36 cases (40.9%) had electrographic status epilepticus. Prior epileptic encephalopathy diagnosis [odds ratio (OR) = 6.57, 95% CI = 1.91-22.59, = 0.003], interictal epileptiform discharges (OR = 46.82, 95%CI = 5.31-412.86, = 0.0005), slow disorganized EEG background (OR = 11.92, 95%CI = 1.31-108.71, = 0.028), and burst-suppression EEG background (OR = 23.64, 95%CI = 1.71-327.57, = 0.018) were the risk factors for electrographic seizures' occurrence. Of the 232 patients, the condition of 179 (77.2%) patients improved and they were discharged, 34 cases (14.7%) were withdrawn, and 18 cases (7.8%) died. The in-hospital death rate was 47.6% (10 in 21 cases) in patients with attenuated/featureless, compared to 0/23 with normal EEG background.
Electrographic status epilepticus occurs in more than one-third of patients with electrographic seizures. vEEG is an efficient method to determine electrographic seizures in children. Abnormal EEG background activity is associated with both electrographic seizures' occurrence and unfavorable in-hospital outcomes.
研究在儿科重症监护病房（PICU）接受床边视频脑电图（vEEG）监测的患者的新生儿脑电图（EEG）背景活动及脑电图癫痫发作情况。
本研究回顾性纳入了232例入住或转入PICU并接受vEEG监测的儿科患者，并在vEEG监测后观察脑电图癫痫持续状态。
中位年龄为1.56岁[95%置信区间（CI）=1.12 - 2.44]。88例患者（37.9%）出现脑电图癫痫发作，其中36例（40.9%）出现脑电图癫痫持续状态。既往癫痫性脑病诊断[比值比（OR）=6.57，95%CI =1.91 - 22.59，P =0.003]、发作间期癫痫样放电（OR =46.82，95%CI =5.31 - 412.86，P =0.0005）、脑电图背景活动缓慢紊乱（OR =11.92，95%CI =1.31 - 108.71，P =0.028）以及爆发抑制脑电图背景（OR =23.64，95%CI =1.
