Zhan Qichen, Han Xuan, Mu Jiankang, Shi Xianqing, Zheng Yuhan, Wang Ting, Cao Tao, Xi Yulu, Weng Zhongpei, Wang Xiaoqing, Cao Peng
School of Pharmacy, Nanjing University of Chinese Medicine Nanjing Jiangsu 210023 China
School of Chinese Medicine, Nanjing University of Chinese Medicine Nanjing Jiangsu 210023 China.
Nanoscale Adv. 2022 Oct 19;4(23):5021-5026. doi: 10.1039/d2na00549b. eCollection 2022 Nov 22.
Hypoxia, a characteristic hallmark of solid tumours, restricts the therapeutic effect of photodynamic therapy (PDT) for cancer treatment. To address this issue, a facile and nanosized oxygen (O) bubble template is established by mixing oxygenated water and water-soluble solvents for guiding hollow polydopamine (HPDA) synthesis, and O is encapsulated in the cavity of HPDA. HPDA with abundant catechol is designed as a carrier for zinc phthalocyanine (ZnPc, a boronic acid modified photosensitizer) borate ester bonds to fabricate nanomedicine (denoted as HZNPs). The and results indicate that O-evolving HZNPs could alleviate tumour hypoxia and enhance PDT-anticancer efficiency. Melanin-like HPDA with a photothermal conversion rate () of 38.2% shows excellent synergistic photothermal therapy (PTT) efficiency in cancer treatment.
缺氧是实体肿瘤的一个典型特征，它限制了光动力疗法（PDT）治疗癌症的效果。为了解决这个问题，通过将含氧水和水溶性溶剂混合来建立一种简便的纳米级氧（O）气泡模板，以指导中空聚多巴胺（HPDA）的合成，并且O被封装在HPDA的腔内。具有丰富儿茶酚的HPDA被设计为锌酞菁（ZnPc，一种硼酸修饰的光敏剂）硼酸酯键的载体，以制备纳米药物（表示为HZNPs）。 结果表明，产生O的HZNPs可以缓解肿瘤缺氧并提高PDT抗癌效率。具有38.2%光热转换率（ ）的黑色素样HPDA在癌症治疗中显示出优异的协同光热疗法（PTT）效率。
