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治疗的替代策略:有前景的非抗生素方法。

Alternative strategies for treatment: Promising non-antibiotic approaches.

作者信息

Hou Chen, Jin Yingqi, Wu Hua, Li Pengyi, Liu Longyun, Zheng Kang, Wang Chuan

机构信息

School of Basic Medicine, Hengyang Medical College, Institute of Pathogenic Biology, University of South China, Hengyang, China.

Department of Clinical Laboratory, Affiliated Hengyang Hospital of Southern Medical University, Hengyang Central Hospital, Hengyang, China.

出版信息

Front Microbiol. 2022 Nov 23;13:987662. doi: 10.3389/fmicb.2022.987662. eCollection 2022.

DOI:10.3389/fmicb.2022.987662
PMID:36504792
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9727249/
Abstract

is an obligate intracellular bacterium where most species are pathogenic and infectious, causing various infectious diseases and complications in humans and animals. Antibiotics are often recommended for the clinical treatment of chlamydial infections. However, extensive research has shown that antibiotics may not be sufficient to eliminate or inhibit infection entirely and have some potential risks, including antibiotic resistance. The impact of chlamydial infection and antibiotic misuse should not be underestimated in public health. This study explores the possibility of new therapeutic techniques, including a review of recent studies on preventing and suppressing chlamydial infection by non-antibiotic compounds.

摘要

是一种专性细胞内细菌,大多数种类具有致病性和传染性,可在人类和动物中引起各种传染病和并发症。抗生素通常被推荐用于衣原体感染的临床治疗。然而,大量研究表明,抗生素可能不足以完全消除或抑制感染,并且存在一些潜在风险,包括抗生素耐药性。衣原体感染和抗生素滥用对公共卫生的影响不容小觑。本研究探讨了新治疗技术的可能性,包括综述近期关于用非抗生素化合物预防和抑制衣原体感染的研究。

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Effects of sustained antibiotic bactericidal treatment on Chlamydia trachomatis-infected epithelial-like cells (HeLa) and monocyte-like cells (THP-1 and U-937).持续抗生素杀菌治疗对沙眼衣原体感染的上皮样细胞(HeLa)和单核细胞样细胞(THP-1和U-937)的影响。
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本文引用的文献

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Link Between Antibiotic Persistence and Antibiotic Resistance in Bacterial Pathogens.抗生素持久性与细菌病原体中抗生素耐药性的关联。
Front Cell Infect Microbiol. 2022 Jul 19;12:900848. doi: 10.3389/fcimb.2022.900848. eCollection 2022.
2
Differential Effects of Small Molecule Inhibitors on the Intracellular Chlamydia Infection.小分子抑制剂对细胞内沙眼衣原体感染的影响差异。
mBio. 2022 Aug 30;13(4):e0107622. doi: 10.1128/mbio.01076-22. Epub 2022 Jun 15.
3
Doxycycline: the universal treatment for anogenital chlamydia.强力霉素:用于治疗肛门生殖器衣原体感染的通用药物。
Lancet Infect Dis. 2022 Aug;22(8):1102-1103. doi: 10.1016/S1473-3099(22)00173-6. Epub 2022 May 9.
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Chlamydia pneumoniae infections and development of lung cancer: systematic review.肺炎衣原体感染与肺癌的发生:系统评价
Infect Agent Cancer. 2022 Mar 22;17(1):11. doi: 10.1186/s13027-022-00425-3.
5
The use of supercytokines, immunocytokines, engager cytokines, and other synthetic cytokines in immunotherapy.在免疫疗法中使用超细胞因子、免疫细胞因子、衔接细胞因子和其他合成细胞因子。
Cell Mol Immunol. 2022 Feb;19(2):192-209. doi: 10.1038/s41423-021-00786-6. Epub 2022 Jan 4.
6
and Activity of (Trifluoromethyl)pyridines as Anti- Agents.并探讨(三氟甲基)吡啶类化合物作为抗剂的活性。
ACS Infect Dis. 2022 Jan 14;8(1):227-241. doi: 10.1021/acsinfecdis.1c00553. Epub 2021 Dec 22.
7
Problems With Understanding Chlamydia trachomatis Immunology.沙眼衣原体免疫学理解的问题。
J Infect Dis. 2022 Jun 1;225(11):2043-2049. doi: 10.1093/infdis/jiab610.
8
An overview of genes and mutations associated with Chlamydiae species' resistance to antibiotics.与衣原体物种对抗生素的耐药性相关的基因和突变概述。
Ann Clin Microbiol Antimicrob. 2021 Sep 3;20(1):59. doi: 10.1186/s12941-021-00465-4.
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mRNA vaccines for infectious diseases: principles, delivery and clinical translation.传染病的 mRNA 疫苗:原理、传递和临床转化。
Nat Rev Drug Discov. 2021 Nov;20(11):817-838. doi: 10.1038/s41573-021-00283-5. Epub 2021 Aug 25.
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Pelvic Inflammatory Disease Due to Neisseria gonorrhoeae and Chlamydia trachomatis: Immune Evasion Mechanisms and Pathogenic Disease Pathways.淋病奈瑟菌和沙眼衣原体引起的盆腔炎:免疫逃逸机制和致病疾病途径。
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