Kacemi Rachid, Campos Maria G
Observatory of Drug-Herb Interactions, Faculty of Pharmacy, Heath Sciences Campus, University of Coimbra, Azinhaga de Santa Comba, 3000-548 Coimbra, Portugal.
Coimbra Chemistry Centre (CQC, FCT Unit 313) (FCTUC), University of Coimbra, Rua Larga, 3004-531 Coimbra, Portugal.
Molecules. 2024 Dec 13;29(24):5893. doi: 10.3390/molecules29245893.
Bee Pollen (BP) has many advantageous properties relying on its multitargeting potential, a new tendency in managing many challenging illnesses. In cancer and neurodegeneration, the multiple effects of BP could be of unequaled importance and need further investigation. Although still limited, available data interestingly spotlights some floral sources with promising activities in line with this investigation. Adopting scoping review methodology, we have identified many crucial bioactivities that are widely recognized to individual BP compounds but remain completely untapped in this valuable bee cocktail. A wide range of these compounds have been recently found to be endowed with great potential in modulating pivotal processes in neurodegeneration and cancer pathophysiology. In addition, some ubiquitous BP compounds have only been recently isolated, while the number of studied BPs remains extremely limited compared to the endless pool of plant species worldwide. We have also elucidated that clinical profits from these promising perspectives are still impeded by challenging hurdles such as limited bioavailability of the studied phytocompounds, diversity and lack of phytochemical standardization of BP, and the difficulty of selective targeting in some pathophysiological mechanisms. We finally present interesting insights to guide future research and pave the way for urgently needed and simplified clinical investigations.
蜂花粉（BP）因其多靶点潜力而具有许多优势特性，这是应对许多疑难病症的一种新趋势。在癌症和神经退行性疾病方面，BP的多种作用可能具有无与伦比的重要性，需要进一步研究。尽管现有数据仍然有限，但有趣的是，这些数据突出了一些具有与本研究相符的有前景活性的花卉来源。采用范围综述方法，我们确定了许多关键的生物活性，这些活性已被广泛认可为BP的个别化合物所具有，但在这种宝贵的蜂产品混合物中仍完全未被开发利用。最近发现，这些化合物中的许多在调节神经退行性疾病和癌症病理生理学的关键过程中具有巨大潜力。此外，一些常见的BP化合物直到最近才被分离出来，而且与全球无尽的植物物种库相比，所研究的BP数量仍然极其有限。我们还阐明，这些有前景的观点所带来的临床益处仍然受到诸多挑战的阻碍，例如所研究的植物化合物生物利用度有限、BP的多样性和缺乏植物化学标准化，以及在某些病理生理机制中进行选择性靶向的困难。我们最终提出了有趣的见解，以指导未来的研究，并为迫切需要且简化的临床研究铺平道路。
